Towards next-generation diagnostics for tuberculosis: identification of novel molecular targets by large-scale comparative genomics.

Fecha de publicación: 15/02/2020 Fecha Ahead of Print: 03/10/2019

Autores de IIS La Fe

Ana Gil Brusola

Autor

Participantes ajenos a IIS La Fe

Goig GA
Torres-Puente M
Mariner-Llicer C
Villamayor LM
Chiner-Oms Á
Borrás R
Comas I

Grupos

Infección Grave

Investigador Principal

María Ángeles Tormo Mas

Abstract

Tuberculosis remains one of the main causes of death worldwide. The long and cumbersome process of culturing Mycobacterium tuberculosis complex (MTBC) bacteria has encouraged the development of specific molecular tools for detecting the pathogen. Most of these tools aim to become novel tuberculosis diagnostics, and big efforts and resources are invested in their development, looking for the endorsement of the main public health agencies. Surprisingly, no study had been conducted where the vast amount of genomic data available is used to identify the best MTBC diagnostic markers.

Datos de la publicación

ISSN/ISSNe:: 1367-4803, 1367-4811
Tipo:: Article
Páginas:: 985-989
DOI:: 10.1093/bioinformatics/btz729
Factor de Impacto:: 3,599 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Goig GA:: Institute of Biomedicine of Valencia (CSIC), Valencia, Spain
Torres-Puente M:: Institute of Biomedicine of Valencia (CSIC), Valencia, Spain
Mariner-Llicer C:: Institute of Biomedicine of Valencia (CSIC), Valencia, Spain
Villamayor LM:: FISABIO Public Health (CSISP), Valencia, Spain
Chiner-Oms Á:: Institute of Biomedicine of Valencia (CSIC), Valencia, Spain
Gil-Brusola A:: La Fe University and Polytechnic Hospital, Valencia, Spain
Borrás R:: University Clinic Hospital, Valencia, Spain

School of Medicine, University of Valencia, Valencia, Spain
Comas I:: Institute of Biomedicine of Valencia (CSIC), Valencia, Spain

CIBER in Epidemiology and Public Health, Madrid, Spain

Keywords

MYCOBACTERIUM-TUBERCULOSIS; MARKERS

Proyectos asociados

BIOMARCADORES INFLAMATORIOS Y CARDÍACOS COMO PREDICTORES DE EVENTOS CARDIOVASCULARES Y MORTALIDAD TRAS EL ALTA EN LA NEUMONÍA ADQUIRIDA EN LA COMUNIDAD.

Investigador Principal: ROSARIO MENÉNDEZ VILLANUEVA

PI13/00583 . INSTITUTO DE SALUD CARLOS III . 2014

ESTUDIO EPIDEMIOLÓGICO PROSPECTIVO DE VIGILANCIA HOSPITALARIA DE LA ENFERMEDAD NEUMOCÓCICA INVASORA EN ADULTOS MAYORES DE 18 AÑOS EN ESPAÑA.

Investigador Principal: MIGUEL SALAVERT LLETÍ

PFI-PRE-2010-01 . 2012

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