Risk factors for anastomotic leakage after colorectal resection in ovarian cancer surgery: A multi-centre study

Autores de IIS La Fe

• Víctor Lago Leal

  Autor

• Pablo Padilla Iserte

  Autor

• Álvaro García-Granero García-Fuster

  Autor

• Luis Javier Matute Tobias

  Autor

• Victoria Fornés Ferrer

  Autor

• Santiago Domingo Del Pozo

  Autor

Participantes ajenos a IIS La Fe

• Fotopoulou, C
• Chiantera, V
• Minig, L
• Gil-Moreno, A
• Cascales-Campos, PA
• Jurado, M
• Tejerizo, A
• Malune, ME
• Di Donna, MC
• Marina, T
• Sanchez-Iglesias, JL
• Olloqui, A

Grupos

• Cirugía digestiva y Cuidados perioperatorios

  

  Leader

  Matteo Frasson

• Medicina Reproductiva

  

  Investigador Principal

  José Morales Roselló

Abstract

Objective. To determine pre-/intraoperative risk factors for anastomotic leak after modified posterior pelvic exenteration (MPE) or colorectal resection in ovarian cancer and to create a practical instrument for predicting anastomotic leak risk. Background. In advanced ovarian cancer surgery, there is rather limited published evidence, drawn from a small sample, providing information about risk factors for anastomotic leak. Methods. Eight hospitals participated in this retrospective study. Data on 695 patients operated for ovarian cancer with primary anastomosis were included (January 2010-June 2018). Twelve pre-/intraoperative variables were analysed as potential independent risk factors for anastomotic leak. A predictive model was created to stablish the risk of anastomotic leak for a given patient. Results. The anastomotic leak rate was 6.6% (46/695; range 1.7%-12.5%). A total of 457 patients were included in the final multivariate analysis. The following variables were found to be independently associated with anastomotic leakage: age at surgery (OR 1.046, 95% CI 1.013-1.080, p = 0.005), serum albumin level (OR 0.621, 95% CI 0.407-0.948, p = 0.027), one or more additional small bowel resections (OR 3.544, 95% CI 1.228-10.23, p = 0.019), manual anastomosis (OR 8.356, 95% CI 1.777-39.301, p = 0.007) and distance of the anastomosis from the anal verge (OR 0.839, 95% CI 0.726-0.971, p = 0.018). Conclusions. Due to the low incidence of AL in ovarian cancer patients, a restrictive stoma policy based on the presence of risk factors should be the actual recommendation. Hand-sewn anastomosis should be avoided. Crown Copyright (C) 2019 Published by Elsevier Inc. All rights reserved.

Keywords

• Anastomotic leak; Ovarian cancer; Risk factors