Clinical application of the sentinel lymph node technique in early ovarian cancer: a pilot study

Autores de IIS La Fe

• Víctor Lago Leal

  Autor

• Pilar Bello Arques

  Autor

• Beatriz Montero Balaguer

  Autor

• Luis Javier Matute Tobias

  Autor

• Pablo Padilla Iserte

  Autor

• Sergio Camilo Lopez Garcia

  Autor

• Laura Marcela Agudelo Cifuentes

  Autor

• Santiago Domingo Del Pozo

  Autor

Grupos

• Medicina Fetal y Reproductiva

• Núcleo de investigación traslacional integrado Urológico de Valencia (NITIUV)

Abstract

Introduction There is limited evidence favoring the use of the sentinel lymph node technique in ovarian cancer, and no standardized approach has been studied. The objective of the present pilot study is to determine the feasibility of the sentinel lymph node technique by applying a clinical algorithm. Methods Patients with confirmed ovarian cancer were included. 99mTc and indocyanine green were injected into the ovarian and infundubulo-pelvic ligament stump. A gamma probe and near-infrared fluorescence imaging were used for sentinel lymph node detection. Results The sentinel lymph node technique was performed in nine patients with a detection rate in the pelvic and/or para-aortic region of 100%. The tracer distribution rates of sentinel lymph nodes in the pelvic and para-aortic regions were 87.5% and 70%, respectively. Conclusion The detection of sentinel lymph nodes in early-stage ovarian cancer appears to be achievable. Based on these results, a clinical trial entitled SENTOV (SENtinel lymph node Technique in OVarian cancer) will be performed.

Keywords

• ovarian cancer; early stage; sentinel lymph node; staging