Portal de recerca
ESTUDIO ABIERTO, ALEATORIZADO, FASE II DE COMBINACIONES DE INHIBIDORES DE PUNTOS DE CONTROL INMUNITARIO CON AXITINIB EN PACIENTES CON CARCINOMA DE CÉLULAS RENALES NO TRATADO PREVIAMENTE LOCALMENTE AVANZADO NO RESECTABLE O METASTÁSICO.
Dades bàsiques
- Protocol:
- BO43936
- EURDRACT:
- 2021-006430-39
- NCT:
- Centre:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Any inici:
- 2023
- Any de finalització:
Objectius del projecte
Objetivo Principal: ? Evaluar la eficacia en el grupo A en comparación con el grupo de control y en el grupo B en comparación con el grupo de control en PCA ? Evaluar la seguridad y la tolerabilidad en el grupo A en comparación con el grupo de control y en el grupo B en comparación con el grupo de control en la población ES Objetivos Secundarios: ? Evaluar la eficacia en el grupo A en comparación con el grupo de control y en el grupo B en comparación con el grupo de control ? Evaluar la respuesta inmunitaria a tiragolumab y RO7247669
Documents
- No hi ha documents
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
[[Tranaslated article]]Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
López DF; (...); Ortiz-Romero, P. L.
Article. 10.1016/j.ad.2022.11.013. 2023
[Translated article] New challenges in advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2024.05.001. 2024
[Translated article] Pharmacokinetic-guided switching from standard half-life factor VIII to extended half-life pegylated factor VIII in haemophilia A therapy in clinical practice.
Chovi-Trull, Maria; (...); Andres, Jose Luis Poveda
Article. 10.1016/j.farma.2024.12.007. 2025
A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma (Dec, 10.1007/s11060-023-04513-1, 2023)
Gately L; (...); Balana C
Correction. 10.1007/s11060-024-04581-x. 2024
A combined analysis of two prospective randomised studies exploring the impact of extended post-radiation temozolomide on survival outcomes in newly diagnosed glioblastoma.
Gately, L.; (...); Balana, C.
Article. 10.1007/s11060-023-04513-1. 2023
A COMBINED ANALYSIS OF TWO RANDOMISED STUDIES EXPLORING THE IMPACT OF EXTENDED POST-RADIATION TEMOZOLOMIDE ON SURVIVAL OUTCOMES IN NEWLY DIAGNOSED GLIOBLASTOMA
Gately, Lucy; (...); Balana, Carmen
Meeting Abstract. 2023
A Gadolinium(III) Complex Based on Pyridoxine Molecule with Single-Ion Magnet and Magnetic Resonance Imaging Properties.
Orts-Arroyo, Marta; (...); Martinez-Lillo, Jose
Article. 10.3390/ijms25042112. 2024
Addressing the challenges of cancer care in older adults: The unique benefits of oncogeriatric evaluation and management.
Martinez-Peromingo, Javier; (...); Girones, Regina
Letter. 10.1016/j.regg.2023.03.002. 2023
Advances in Transversal Topics Applicable to the Care of Bladder Cancer Patients in the Real-World Setting
Garrido Siles, Marga; (...); Angel Climent, Miguel
Review. 10.3390/cancers14163968. 2022
Amyloid brain-dedicated PET images can diagnose Alzheimer's pathology with Centiloid Scale.
Gandia-Ferrero MT; (...); Martí-Bonmatí L
Article. 10.1016/j.ejmp.2024.103345. 2024
Anti-endotoxin antibodies consumption in cardiovascular collapse: Pathophysiological concerns.
Villarreal, E.; (...); Vila, J.
Article. 10.1016/j.medine.2022.04.019. 2022
Benefits of physical activity self-monitoring in patients with haemophilia: a prospective study with one-year follow-up.
Pérez-Alenda S; (...); Núñez-Cortés R
Article. 10.1111/hae.14988. 2024
Bladder cancer patients have increased NETosis and impaired DNaseI-mediated NET degradation that can be therapeutically restored in vitro.
Article. 10.3389/fimmu.2023.1171065. 2023
Bladder Preservation with Durvalumab plus Tremelimumab and Concurrent Radiotherapy in Patients with Localized Muscle-Invasive Bladder Cancer (IMMUNOPRESERVE): A Phase II Spanish Oncology GenitoUrinary Group Trial.
Garcia-Del-Muro, Xavier; (...); Alemany, Ramon
Article. 10.1158/1078-0432.CCR-24-2636. 2025
ComBat harmonization in different PET imaging scenarios
Gandia-Ferrero, M.; (...); Marti-Bonmati, L.
Meeting Abstract. 2023
Correction: Update on the management of elderly patients with colorectal cancer.
Soler-González G; (...); Gironés-Sarrió R
Correction. 10.1007/s12094-023-03351-x. 2024
Cost-effectiveness and cost-utility analysis of haemate-P versus other von willebrand disease treatments in Spain.
Megias-Vericat, Juan E; (...); Yan, Songkai
Article. 10.1080/13696998.2025.2474886. 2025
Development and testing of a mobile app for systematic collection of patient-reported outcomes (PROs) in patients with hemophilia.
Megias-Vericat, J E; (...); Poveda Andres, J L
Letter. 10.1016/j.thromres.2024.109122. 2024
Drug-drug interactions associated with FLT3 inhibitors for acute myeloblastic leukemia: current landscape.
Solana-Altabella, Antonio; (...); Montesinos, Pau
Article. 10.1080/17512433.2023.2174523. 2023
Endothelial Biomarkers Are Superior to Classic Inflammatory Biomarkers in Community-Acquired Pneumonia.
González-Jiménez P; (...); Méndez R
Article. 10.3390/biomedicines12102413. 2024
Endothelial Damage, Neutrophil Extracellular Traps and Platelet Activation in COVID-19 vs. Community-Acquired Pneumonia: A Case-Control Study.
González-Jiménez P; (...); Menéndez R
Article. 10.3390/ijms241713194. 2023
Enhancing Prostate Tumor Biobanking Reliability with Improved Sampling Technique and Histological Characterization.
Giner Moreno E; (...); Ramos Soler D
Article. 10.3791/65635. 2023
Expert consensus to optimize the management of older adult patients with advanced EGFR-mutated non-small cell lung cancer.
Nadal E; (...); Gironés R
Article. 10.1007/s12094-023-03286-3. 2023
Exploring management and outcomes of elderly patients with glioblastoma using data from two randomised trials (GEINO1401/EX-TEM).
Gately L; (...); Balana C
Article. 10.1007/s11060-024-04668-5. 2024
Extra-Skeletal Osteosarcoma of the Prostate After Treated Prostatic Acinar Adenocarcinoma: A Case Report and Review of the Literature.
García CR; (...); Segura FG
Article. 10.1177/10668969241283735. 2024
Final database lock results of the phase 2 cohort of lenvatinib plus pembrolizumab for progressive disease after a PD-1/PD-L1-containing therapy in metastatic clear cell renal cell carcinoma
Lee, Chung-Han; (...); Motzer, Robert J.
Meeting Abstract. 2023
Free automatic software for quality assurance of computed tomography calibration, edges and radiomics metrics reproducibility.
Saborido-Moral, Juan D.; (...); Carles, Montserrat
Article. 10.1016/j.ejmp.2023.103153. 2023
Glasdegib in combination with temozolomide and radiotherapy in patients with newly diagnosed glioblastoma: Phase Ib/II GEINO 1602 trial
Vaz, M. A.; (...); Girones, R.
Meeting Abstract. 10.1016/j.annonc.2023.09.1695. 2023
Impact of a comprehensive geriatric assessment to manage elderly patients with locally advanced non-small-cell lung cancers: a multicenter prospective study.
Rondan, Maria Arnal; (...); Sarrio, Regina Girones
Article. 10.1007/s12094-024-03657-4. 2024
Incidence and Risk Factors for Development of Cardiac Toxicity in Adult Patients with Newly Diagnosed Acute Myeloid Leukemia
Boluda, Blanca; (...); Montesinos, Pau
Article. 10.3390/cancers15082267. 2023
Initial and Residual Cardiovascular Damage Remaining at Day 30 in Community-acquired Pneumonia
Ocana, R. Mendez; (...); Menendez, R.
Meeting Abstract. https://doi.org/10.1164/ajrccm-conference.2024.209.1_MeetingAbstracts.A6241. 2024
Leave no one behind: A global survey of the current state of geriatric oncology practice by SIOG national representatives.
Mizutani, Tomonori; (...); Kanesvaran, Ravindran
Article. 10.1016/j.jgo.2024.101709. 2024
Lenvatinib plus Pembrolizumab Following Immune Checkpoint Inhibitor Treatment in Patients with Metastatic Clear Cell Renal Cell Carcinoma: Results from Study 111/KEYNOTE-146.
Lee, Chung-Han; (...); Motzer, Robert J
Letter. 10.1016/j.eururo.2024.05.003. 2024
Mental, emotional and social dimensions of quality of life and their relationship with physical and functional status in adults with haemophilia.
Rodríguez MA; (...); Chimeno-Hernández A
Article. 10.1016/j.thromres.2024.109181. 2024
Neutrophil Extracellular Traps and Platelet Activation for Identifying Severe Episodes and Clinical Trajectories in COVID-19
González-Jiménez P; (...); Menéndez R
Article. 10.3390/ijms24076690. 2023
New challenges of advanced therapies.
Megías-Vericat JE; (...); Poveda Andrés JL
Article. 10.1016/j.farma.2023.11.008. 2024
Objective Image Quality Comparison Between Brain-Dedicated PET and PET/CT Scanners.
Gandia-Ferrero MT; (...); Martí-Bonmatí L
Article. 10.1007/s10916-023-01984-7. 2023
P25.03.B RWD OF IDH MUTANT GLIOMAS IN SPAIN, A RETSINE - GEINO STUDY
Mazariegos, M.; (...); Pineda, E.
Meeting Abstract. 10.1093/neuonc/noae144.446. 2024
Pharmacogenetics in Response to Biological Agents in Inflammatory Bowel Disease: A Systematic Review.
Ballesta-Lopez, Octavio; (...); Poveda-Andres, Jose Luis
Article. 10.3390/ijms26041760. 2025
Phase II trial evaluating olaparib maintenance in patients with metastatic castration resistant prostate cancer (mCRPC) after docetaxel treatment, reaching partial or stable response: SOGUG-IMANOL study.
Juan Fita, Maria Jose; (...); Heras, Lucia
Meeting Abstract. 2023
Phase II Trial Evaluating Olaparib Maintenance in Patients with Metastatic Castration-Resistant Prostate Cancer Responsive or Stabilized on Docetaxel Treatment: SOGUG-IMANOL Study.
Juan Fita, Maria Jose; (...); Angel Climent, Miguel
Article. 10.3390/cancers15215223. 2023
Predictive Value of First Amniotic Sac IL-6 and Maternal Blood CRP for Emergency Cerclage Success in Twin Pregnancies.
Diago-Munoz, Diana Maria; (...); Diago-Almela, Vicente Jose
Article. 10.3390/jpm15010037. 2025
Prognostic role of geriatric assessment (GA) in patients with metastatic prostate cancer (MPCaP) attended in medical oncology.
Girones, Regina, Arnal, Maria, Forcano, Silvia
Meeting Abstract. 2023
Relationship between neuroimaging and emotion recognition in Mild Cognitive Impairment patients.
Gandia-Ferrero, Maria Teresa; (...); Marti-Bonmati, Luis
Article. 10.1016/j.bbr.2023.114844. 2024
Safety and efficacy of glasdegib in combination with temozolomide and radiotherapy in patients with newly diagnosed glioblastoma: Phase Ib/II GEINO 1602 trial
Vaz, Maria Angeles; (...); Martinez-Garcia, Maria
Meeting Abstract. 2022
SEOM-GEINO clinical guidelines for high-grade gliomas of adulthood (2022).
Segura, Pedro Perez; (...); Losada, Estela Pineda
Article. 10.1007/s12094-023-03245-y. 2023
Sequential treatment of High-risk Neuroblastoma combining I-131 MIBG high-dose and Topotecan. First experience
Orrego, N.; (...); Bello-Arques, P.
Meeting Abstract. 2023
SIOG COVID-19 Working Group recommendations on COVID-19 therapeutic approaches in older adults with cancer.
Russo, Chiara; (...); Battisti NML
Article. 10.1016/j.jgo.2023.101564. 2023
SOGUG-AVELUMAB_RWD: Comprehensive analysis of real-word data to evaluate the effectiveness and safety of avelumab maintenance therapy in patients with stage IV urothelial carcinoma conducted in Spain.
Juan Fita, Maria Jose; (...); Molina Diaz, Aurea
Meeting Abstract. https://doi.org/10.1200/JCO.2024.42.16_suppl.e1656. 2024
State of the art and future perspectives of new radionuclides in Nuclear Medicine.
Rosales, J J; (...); Quincoces, G
Article. 10.1016/j.remnie.2025.500082. 2025
State of the scientific evidence and recommendations for the management of older patients with gastric cancer.
Paredero-Perez, Irene; (...); Girones-Sarrio, Regina
Article. 10.1016/j.jgo.2023.101657. 2023
Strategies to enhance management of HER2-positive breast cancer in the elderly: an expert consensus perspective.
Del Barco, Sonia; (...); Servitja, Sonia
Article. 10.1007/s12094-024-03838-1. 2025
Update on the management of elderly patients with colorectal cancer.
Soler-Gonzalez, Gemma; (...); Girones-Sarrio, Regina
Article. 10.1007/s12094-023-03243-0. 2023
Update on the management of older patients with pancreatic adenocarcinoma: a perspective from medical oncology.
Guillot Morales M; (...); Gironés Sarrió R
Article. 10.1007/s12094-024-03386-8. 2024
Updated SIOG COVID-19 working group recommendations on COVID-19 vaccination among older adults with cancer.
Soto-Perez-de-Celis, Enrique; (...); Battisti, Nicolo Matteo Luca
Article. 10.1016/j.jgo.2022.07.005. 2022
Y-90 PET/MR imaging optimization with a Bayesian penalized likelihood reconstruction algorithm.
Calatayud-Jordan, Jose; (...); Torres-Espallardo, Irene
Article. 10.1007/s13246-024-01452-7. 2024