Portal de investigación
Creación de organoides endometriales y ováricos mediante el uso de matrices extracelulares desde órganos escelularizados.
Datos básicos
- Protocolo:
- FPU20/00251
- EUDRACT:
- NCT:
- Centro:
- Año de incio:
- 2021
- Año de finalización:
- 2025
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
A biomechanical assessment of tissue-engineered polymer neo-uteri after orthotopic implantation.
Nordberg RC; (...); Loboa EG
Article. 10.1016/j.xfss.2023.12.005. 2023
Addressing Key Questions in Organoid Models: Who, Where, How, and Why?
Gomez-Alvarez, Maria; (...); Cervello, Irene
Article. 10.3390/ijms242116014. 2023
Advances of xenogeneic ovarian extracellular matrix hydrogels for in vitro follicle development and oocyte maturation.
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1016/j.bioadv.2023.213480. 2023
Bioengineering an Ovarian-Specific ECM Hydrogel to Treat Premature Ovarian Failure
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2023
Bioengineering trends in female reproduction: a systematic review
Frances-Herrero, Emilio; (...); Cervello, Irene
Review. 10.1093/humupd/dmac025. 2022
Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends.
Agustina-Hernandez, Marcos; (...); Cervello, Irene
Article. 10.3389/fbioe.2024.1495338. 2024
EFFECT OF HUMAN UMBILICAL CORD BLOOD PLATELET-RICH PLASMA COMBINED WITH EXTRACELLULAR MATRIX HYDROGELS ON IMMUNOCOMPETENT ENDOMETRIAL DAMAGE: MURINE MODELS
Rodriguez Eguren, Adolfo; (...); Cervello, Irene
Meeting Abstract. 2022
Effects of In Vitro Culture Systems with Fallopian Tube Extracellular Matrix on Rabbit Embryo Gene Expression.
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2024
Endometrial Extracellular Matrix Hydrogel Alleviates Epithelial-toMesenchymal Transition Triggered by Human Umbilical Cord PlateletRich Plasma in Human Endometrial Organoids.
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Meeting Abstract. 2024
Endometrial Extracellular Matrix Hydrogels as Alternatives to Matrigel for Culturing Human Endometrial Organoids
Gomez-Alvarez, Maria; (...); Cervello, Irene
Meeting Abstract. 2023
Endometrial extracellular vesicles regulate processes related to embryo development and implantation in human blastocysts
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Article. 10.1093/humrep/deae256. 2024
Enhancing Development of Murine Follicles In Vitro Using Extracellular Matrix from Decellularized Bovine Ovarian Cortex
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2022
EPITHELIAL-TO-MESENCHYMAL TRANSITION INDUCTION BY HUMAN UMBILICAL CORD PLATELET-RICH PLASMA IN HUMAN ENDOMETRIAL ORGANOIDS: DIFFERENTIATION STATE MATTERS
Agustina-Hernandez, Marcos; (...); Cervello, Irene
Meeting Abstract. 10.1016/j.fertnstert.2024.07.263. 2024
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.3390/jpm12020219. 2022
Evolution of biotechnological advances and regenerative therapies for endometrial disorders: a systematic review.
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Article. 10.1093/humupd/dmae013. 2024
Fallopian tube extracellular matrix hydrogels for in vitro embryo culture in rabbit models: A post-natal study
Frances, E.; (...); Cervello, I.
Meeting Abstract. 2022
Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine
Francés-Herrero E; (...); Cervelló I
Article. 10.3390/ijms23073765. 2022
Generation of Complex 3D Human Endometrial Assembloids with Epithelial Organoids and Stromal Stem Cell Lines.
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Meeting Abstract. 2022
GLOBAL DELETION OF MITOCHONDRIAL PINK1 GENE INDUCES LOSS OF FOLLICULAR RESERVE AND PRODUCES FEMALE INFERTILITY
Rodriguez Eguren, Adolfo; (...); Seli, Emre
Meeting Abstract. 2023
Growth Factor-Enriched Xenogeneic Ovarian ECM Hydrogels: A Promising Treatment for Premature Ovarian Failure.
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2024
Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models.
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1016/j.actbio.2024.07.056. 2024
Human Adenomyosis Endometrial Organoids Recapitulate Disease Pathological Features and Show Dysregulated Expression of Implantation and Placentation Biomarkers
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Human endometrial organoids embedded in hybrid endometrial-derived hydrogels as a biocompatible treatment for endometrial pathologies in preclinical models
Gomez-Alvarez, M.; (...); Cervello, I.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.1104. 2024
Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models.
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Article. 10.1093/hropen/hoac053. 2023
Human Umbilical Cord Platelet-Rich Plasma: Metabolomic, Proteomic, and Wound Healing Studies in Endometrial Stem Cells.
Bueno-Fernandez, Clara; (...); Cervello, Irene
Meeting Abstract. 2024
Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Review. 10.3390/ijms232415942. 2022
Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives.
Gomez-alvarez, Maria; (...); Cervello, Irene
Article. 10.1002/adhm.202303838. 2023
MITOPHAGY-REGULATING GENE PARKIN IS REQUIRED FOR FEMALE FERTILITY
Eguren, Adolfo Rodriguez; (...); Seli, Emre
Meeting Abstract. 2023
Murine Oocyte Maturation and Developmental Competence Using Biocompatible Hydrogel Based on Decellularized Bovine Ovarian Cortex
Lopez, Rosalba; (...); Cervello, Irene
Meeting Abstract. 2022
Oviductal extracellular matrix hydrogels enhance in vitro culture of rabbit embryos and reduce deficiencies during assisted reproductive technologies
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1038/s41598-024-77583-4. 2024
Predicted COVID-19 molecular effects on endometrium reveal key dysregulated genes and functions
Henarejos-Castillo, I; (...); Diaz-Gimeno, P.
Article. 10.1093/molehr/gaac035. 2022
Role of Endometrial Extracellular Vesicles miRNAs as Potential Autocrine Regulators of Gene Expression During Embryo Implantation Process in Adenomyosis.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2024
Standard-dose Vitamin D supplementation as an effective and safe non-hormonal treatment for the prevention of uterine fibroid growth in reproductive-age women: A pilot study
Orive, A.; (...); Ferrero, H.
Meeting Abstract. 2023
The Effects of Platelet-Rich Plasma Derived from Human Umbilical Cord Blood in Human Endometrial Organoids
Gomez-Alvarez, Maria; (...); Cervello, Irene
Meeting Abstract. 2023
Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01182-7. 2024
Transcriptomic Analysis of Adenomyosis Mid-Secretory Endometrial Organoids Reveals Deregulated Molecular Mechanisms Involved in Implantation Failure and Pregnancy Loss
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2023
Transcriptomic analysis reveals deregulated molecular mechanisms related to miscarriage, preeclampsia, and pregnancy complications during gestational endometrial phase in adenomyosis
Juarez-Barber, E.; (...); Ferrero, H.
Meeting Abstract. 2023
Transcriptomic Dysregulation in the Endometrium of COVID-19 Patients: A Next-Generation Sequencing Approach.
De Miguel-Gomez, Lucia; (...); Cervello, Irene
Meeting Abstract. 2022
Uterine Repair Mechanisms Are Potentiated by Mesenchymal Stem Cells and Decellularized Tissue Grafts Through Elevated Vegf, Cd44, and Itgb1 Gene Expression
Bandstein, Sara; (...); Hellstrom, Mats
Article. 10.3390/bioengineering11121268. 2024