Portal de recerca
Organoides endometriales de pacientes con endometriosis como modelo para definir mecanismos moleculares implicados en su infertilidad y detectar fármacos de manera personalizada.
Dades bàsiques
- Protocol:
- PI21/00184
- EURDRACT:
- NCT:
- Centre:
- Fundación IVI
- Any inici:
- 2022
- Any de finalització:
- 2025
Documents
- No hi ha documents
Participants
Grups d'Investigació
Finançadors - Promotors
Resultats de l'Assaig Clínic
Advances of xenogeneic ovarian extracellular matrix hydrogels for in vitro follicle development and oocyte maturation.
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1016/j.bioadv.2023.213480. 2023
Bioengineering an Ovarian-Specific ECM Hydrogel to Treat Premature Ovarian Failure
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2023
Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends.
Agustina-Hernandez, Marcos; (...); Cervello, Irene
Article. 10.3389/fbioe.2024.1495338. 2024
Cerebroplacental Ratio Prediction of Intrapartum Fetal Compromise according to the Interval to Delivery.
Morales-Rosello, Jose; (...); Perales Marin, Alfredo
Article. 10.1159/000525162. 2022
Correction to: Impact of Endometrial Receptivity Analysis on Pregnancy Outcomes In Patients Undergoing Embryo Transfer: A Systematic Review and Meta-Analysis.
Zolfaroli, Irene; (...); Rubio, Jose Maria Rubio
Correction. 10.1007/s10815-023-02808-w. 2023
Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.3390/biomedicines10061279. 2022
Deciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach.
Medina-Laver Y; (...); Dominguez F
Article. 10.1093/humrep/deae044. 2024
Diagnosis of intraamniotic inflammation by measuring vaginal interleukin-6 in patients with cervical insufficiency: could amniocentesis be avoided?
Diago Muñoz DM; (...); Diago Almela, Vicente Jose
Article. 10.1080/14767058.2022.2029838. 2022
Doxercalciferol Decreases Uterine Fibroid Growth Rate Through the Regulation of ECM Synthesis and Cell Proliferation
Corachan, Ana; (...); Al-Hendy, Ayman
Meeting Abstract. 2023
ECO-LEAK PROJECT: DIAGNOSIS OF ANASTOMOTIC LEAK BY THE USE OF TRANSVAGINAL ULTRASOUND
Lago, Victor; (...); Domingo, Santiago
Meeting Abstract. 10.1136/ijgc-2023-ESGO.242. 2023
ECO-LEAK technique: early detection of colorectal anastomotic leakage by transvaginal ultrasound.
Lago, Victor; (...); Domingo, Santiago
Article. 10.1136/ijgc-2022-003886. 2022
Effect of Adherence to the Mediterranean Diet on Maternal Iron Related Biochemical Parameters during Pregnancy and Gestational Weight Gain.
Morales-Suarez-Varela, Maria; (...); Pico, Yolanda
Article. 10.3390/life13051138. 2023
EFFECT OF HUMAN UMBILICAL CORD BLOOD PLATELET-RICH PLASMA COMBINED WITH EXTRACELLULAR MATRIX HYDROGELS ON IMMUNOCOMPETENT ENDOMETRIAL DAMAGE: MURINE MODELS
Rodriguez Eguren, Adolfo; (...); Cervello, Irene
Meeting Abstract. 2022
Effects of In Vitro Culture Systems with Fallopian Tube Extracellular Matrix on Rabbit Embryo Gene Expression.
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2024
Endometrial Extracellular Matrix Hydrogel Alleviates Epithelial-toMesenchymal Transition Triggered by Human Umbilical Cord PlateletRich Plasma in Human Endometrial Organoids.
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Meeting Abstract. 2024
Endometrial Extracellular Matrix Hydrogels as Alternatives to Matrigel for Culturing Human Endometrial Organoids
Gomez-Alvarez, Maria; (...); Cervello, Irene
Meeting Abstract. 2023
Endometrial extracellular vesicles regulate processes related to embryo development and implantation in human blastocysts
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Article. 10.1093/humrep/deae256. 2024
EPITHELIAL-TO-MESENCHYMAL TRANSITION INDUCTION BY HUMAN UMBILICAL CORD PLATELET-RICH PLASMA IN HUMAN ENDOMETRIAL ORGANOIDS: DIFFERENTIATION STATE MATTERS
Agustina-Hernandez, Marcos; (...); Cervello, Irene
Meeting Abstract. 10.1016/j.fertnstert.2024.07.263. 2024
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.3390/jpm12020219. 2022
EXTRACELLULAR VESICLES SECRETED BY ENDOMETRIAL ORGANOIDS FROM ADENOMYOSIS PATIENTS CONTAIN MIRNAS IMPLICATED IN DISEASE DEVELOPMENT, EMBRYO IMPLANTATION FAILURE AND PREGNANCY DISORDERS
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Frasier syndrome: A case report
Trelis-Blanes, A.; (...); Monzo-Miralles, A. M.
Article. 10.1016/j.gine.2022.100827. 2023
Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine
Francés-Herrero E; (...); Cervelló I
Article. 10.3390/ijms23073765. 2022
GESTACOVID Project: Psychological and Perinatal Effects in Spanish Pregnant Women Subjected to Strict Confinement Due to the COVID-19 Pandemic and Their Evolution during De-Escalation
Nieto-Tous, Mar; (...); Monfort-Ortiz, Rogelio
Article. 10.3390/jcm13010248. 2024
Growth Factor-Enriched Xenogeneic Ovarian ECM Hydrogels: A Promising Treatment for Premature Ovarian Failure.
Frances-Herrero, Emilio; (...); Cervello, Irene
Meeting Abstract. 2024
Growth factor-loaded ovarian extracellular matrix hydrogels promote in vivo ovarian niche regeneration and enhance fertility in premature ovarian insufficiency preclinical models.
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1016/j.actbio.2024.07.056. 2024
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/beta-catenin and TGF-beta pathways.
Carbajo-García MC; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01060-2. 2023
Healthy mothers with normal cardiotocograms at term. Is maternal age a true determinant of perinatal outcome?
Morales-Rosello, Jose; (...); Perales Marin, Alfredo
Article. 10.1080/14767058.2022.2057794. 2022
Human Adenomyosis Endometrial Organoids Recapitulate Disease Pathological Features and Show Dysregulated Expression of Implantation and Placentation Biomarkers
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation.
Segura-Benítez M; (...); Ferrero H
Article. 10.1093/humrep/dead138. 2023
HUMAN BLASTOCYSTS UPTAKE EXTRACELLULAR VESICLES SECRETED BY PRIMARY ENDOMETRIAL EPITHELIAL CELLS CONTAINING MIRNAS RELATED TO IMPLANTATION AND EARLY EMBRYO DEVELOPMENT
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Human endometrial organoids embedded in hybrid endometrial-derived hydrogels as a biocompatible treatment for endometrial pathologies in preclinical models
Gomez-Alvarez, M.; (...); Cervello, I.
Meeting Abstract. https://doi.org/10.1093/humrep/deae108.1104. 2024
Human umbilical cord platelet-rich plasma to treat endometrial pathologies: methodology, composition and pre-clinical models.
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Article. 10.1093/hropen/hoac053. 2023
Human Umbilical Cord Platelet-Rich Plasma: Metabolomic, Proteomic, and Wound Healing Studies in Endometrial Stem Cells.
Bueno-Fernandez, Clara; (...); Cervello, Irene
Meeting Abstract. 2024
Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Review. 10.3390/ijms232415942. 2022
Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives.
Gomez-alvarez, Maria; (...); Cervello, Irene
Article. 10.1002/adhm.202303838. 2023
Impact of prolonged embryo storage on reproductive and neonatal outcomes: a systematic review and meta-analysis.
Zolfaroli I; (...); Monzó Miralles A
Article. 10.1007/s10815-024-03283-7. 2024
In Silico Saturation Mutagenesis Identifies Novel Driver Genes in Uterine Fibroids
Machado-Lopez, Alba; (...); Mas, Aymara
Meeting Abstract. 2022
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix and vesicles.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1002/path.5920. 2022
Integrative Genomic and Transcriptomic Profiling Reveals a Differential Molecular Signature in Uterine Leiomyoma versus Leiomyosarcoma.
Machado-Lopez A; (...); Mas A
Article. 10.3390/ijms23042190. 2022
Metformin Treatment Decreases Clinical Miscarriage and Improves Live Birth Rates in Infertile Patients with Insulin Resistance.
Belen Albert, Ana; (...); Ferrero, Hortensia
Meeting Abstract. 2024
MicroRNA-132 is overexpressed in fetuses with late-onset fetal growth restriction.
Morales-Rosello, Jose; (...); Perales-Marin, Alfredo
Article. 10.1002/hsr2.558. 2022
MULTI-OMIC ANALYSIS OF ENDOMETRIAL DECIDUALIZATION RESISTANCE UNVEILS A MOSAIC EPITHELIAL-STROMAL SHIFT
Munoz Blat, Irene; (...); Garrido-Gomez, Tamara
Meeting Abstract. 10.1016/j.fertnstert.2024.08.147. 2024
Outperformance of interleukin-6 over placental alpha microglobulin-1 to predict preterm delivery in symptomatic women.
Roca-Prats, Alba; (...); Perales-Marin, Alfredo
Article. 10.1016/j.ajogmf.2023.101125. 2023
Oviductal extracellular matrix hydrogels enhance in vitro culture of rabbit embryos and reduce deficiencies during assisted reproductive technologies
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.1038/s41598-024-77583-4. 2024
Physical examination-indicated cerclage in twin pregnancies compared with singleton pregnancies.
Diago-Munoz, D. M.; (...); Diago-Almela, V. J.
Article. 10.1080/14767058.2023.2228963. 2023
Potential Role of Nervous System Related Functions in Uterine Leiomyoma Pathogenesis
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Predictive Value of First Amniotic Sac IL-6 and Maternal Blood CRP for Emergency Cerclage Success in Twin Pregnancies.
Diago-Munoz, Diana Maria; (...); Diago-Almela, Vicente Jose
Article. 10.3390/jpm15010037. 2025
Predictors of adverse perinatal outcome up to 34 weeks, a multivariable analysis study.
Morales-Rosello, Jose; (...); Perales Marin, Alfredo
Article. 10.1080/01443615.2021.1998891. 2022
Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation.
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Article. 10.1186/s12958-021-00879-x. 2022
Risk of Gestational Diabetes Due to Maternal and Partner Smoking.
Morales-Suarez-Varela, Maria; (...); Llopis-Gonzalez, Agustin
Article. 10.3390/ijerph19020925. 2022
Role of Endometrial Extracellular Vesicles miRNAs as Potential Autocrine Regulators of Gene Expression During Embryo Implantation Process in Adenomyosis.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2024
Social Support and Mental Health in the Postpartum Period in Times of SARS-CoV-2 Pandemic: Spanish Multicentre Cohort Study.
Brik, Maia; (...); Carreras, Elena
Article. 10.3390/ijerph192315445. 2022
The effectiveness of cervical cerclage in twin pregnancies with a mid-trimester short cervix: A retrospective cohort study.
Ferro, Jaime; (...); Serra, Vicente
Article. 10.1016/j.ejogrb.2023.12.029. 2023
The Effects of Platelet-Rich Plasma Derived from Human Umbilical Cord Blood in Human Endometrial Organoids
Gomez-Alvarez, Maria; (...); Cervello, Irene
Meeting Abstract. 2023
THE TIMING OF PROGESTERONE CORRECTED AFTER ENDOMETRIAL TRANSCRIPTOMI( ANALYSIS DI)ES NOT IMPROVE REPRODUCTIVE OUTCOME IN WOMEN WITH ADENGJD TOMS AND NON -RECEPTIVE ENDONIETRIUM
Cozzolino, Mauro; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Timing of Delivery for Twins With Growth Discordance and Growth Restriction An Individual Participant Data Meta-analysis
Koch, Ashlee K.; (...); Li, Wentao
Article. 10.1097/AOG.0000000000004789. 2022
Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01182-7. 2024
Transcriptomic Analysis of Adenomyosis Mid-Secretory Endometrial Organoids Reveals Deregulated Molecular Mechanisms Involved in Implantation Failure and Pregnancy Loss
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2023
UNVEILING ENDOMETRIOSIS: TRANSCRIPTOMIC PROFILING REVEALS MOLECULAR DYSREGULATION IN GESTATIONAL ENDOMETRIAL ORGANOIDS.
Bas-Rivas, Alba; (...); Ferrero, Hortensia
Meeting Abstract. 10.1016/j.fertnstert.2024.07.589. 2024
Uterine fibroid surgical treatment
Satorres, Elena; (...); Monleon, Javier
Editorial Material. 10.1016/j.medcli.2023.07.008. 2023
Vaginal Progesterone for Preventing Preterm Birth and Adverse Perinatal Outcomes in Twin Gestations: A Systematic Review and Meta-analysis
Conde-Agudelo, Agustin; (...); Nicolaides, Kypros H.
Article. 10.1097/01.ogx.0001025800.90686.21. 2024
Vaginal progesterone for preventing preterm birth and adverse perinatal outcomes in twin gestations: a systematic review and meta-analysis.
Conde-Agudelo, Agustin; (...); Nicolaides, Kypros H
Article. 10.1016/j.ajog.2023.05.010. 2023