Portal de investigación
Aplicaciones de los cultivos tridimensionales en reproducción.
Datos básicos
- Código:
- ACIF/2017/118
- Protocolo:
- ACIF/2017/118
- EUDRACT:
- NCT:
- Centro:
- HOSPITAL UNIVERSITARI I POLITÈCNIC LA FE
- Dotación:
- 85.689,00 €
- Año de incio:
- 2018
- Año de finalización:
- 2021
Documentos
- No hay documentos
Participantes
Financiadores - Promotores
Resultados del Ensayo Clínico
5-aza-2 '-deoxycitidine inhibits cell proliferation, extracellular matrix formation and Wnt/beta-catenin pathway in human uterine leiomyomas
Carbajo-García MC; (...); Ferrero H
Article. 10.1186/s12958-021-00790-5. 2021
A Natural Xenogeneic Endometrial Extracellular Matrix Hydrogel Toward Improving Current Human in vitro Models and Future in vivo Applications.
López-Martínez S; (...); Cervelló I
Article. 10.3389/fbioe.2021.639688. 2021
Bioengineered endometrial hydrogels with growth factors promote tissue regeneration and restore fertility in murine models.
Lopez-Martinez, Sara; (...); Cervello, Irene
Article. 10.1016/j.actbio.2021.08.025. 2021
Bioengineering Endometrial Extracellular Matrix Hydrogels: A New Option to Improve Human Three-dimensional Endometrial Cell Culture and Organoid Development.
Lopez-Martinez, S; (...); Cervello, I
Meeting Abstract. 2020
Bioengineering strategies of the uterus towards improving current investigative models and female reproductive health
Campo, H, Cervello, I, Pellicer, A
Article. 2019
Biotechnological progresses in modelling the human endometrium: the evolution of current in vitro techniques and emerging trends.
Agustina-Hernandez, Marcos; (...); Cervello, Irene
Article. 10.3389/fbioe.2024.1495338. 2024
Comparison of different sources of platelet-rich plasma as treatment option for infertility-causing endometrial pathologies.
de Miguel-Gómez L; (...); Cervelló I
Article. 10.1016/j.fertnstert.2020.07.053. 2020
Correlation of Methylation Status and Gene Expression Shows Epigenetics Involvement in Key Biological Processes of Uterine Leiomyoma Development.
Carbajo-Garcia, MC; (...); Ferrero, Hortensia
Meeting Abstract. 2021
COVID19-free endometrium: Undetectable viral RNA in endometrial biopsies from positive symptomatic SARS-CoV-2 women
De Miguel-Gomez, L; (...); Cervello, I
Meeting Abstract. 2021
Decellularization Methods of Ovary in Tissue Engineering.
Campo H, López-Martínez S, Cervelló I
Article. 10.1007/978-3-030-82735-9_11. 2021
Decellularization Methods of Vagina and Cervix in Tissue Engineering.
López-Martínez S, Campo H, Cervelló I
Article. 10.1007/978-3-030-82735-9_13. 2021
Deciphering the Role of Histone Modifications in Uterine Leiomyoma: Acetylation of H3K27 Regulates the Expression of Genes Involved in Proliferation, Cell Signaling, Cell Transport, Angiogenesis and Extracellular Matrix Formation.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.3390/biomedicines10061279. 2022
Development of Decellularized Oviductal Hydrogels as a Support for Rabbit Embryo Culture.
Francés-Herrero E; (...); Cervelló I
Article. 10.1007/s43032-020-00446-6. 2021
DEVELOPMENT OF SECRETOR AND GESTATIONAL PATIENT-DERIVED ORGANOIDS FROM ADENOMYOSIS DISEASE AS AN IN VITRO MODELTO STUDY ADENOMYOSIS-RELATED INFERTILITY AND PERSONALIZED DRUG SCREENING.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2021
Doxercalciferol Decreases Uterine Fibroid Growth Rate Through the Regulation of ECM Synthesis and Cell Proliferation
Corachan, Ana; (...); Al-Hendy, Ayman
Meeting Abstract. 2023
Effects of Vitamin D in Human Uterine Leiomyoma Growth in a Xenograft Animal Model.
Corachan, A; (...); Pellicer, A
Meeting Abstract. 2019
Endometrial extracellular vesicles regulate processes related to embryo development and implantation in human blastocysts
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Article. 10.1093/humrep/deae256. 2024
Establishment of Adenomyosis Organoids as a Preclinical Model to Study Infertility.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.3390/jpm12020219. 2022
Evaluation of PAI-1 in endometriosis using a homologous immunocompetent mouse model
Buigues, A; (...); Gomez, R
Article. 10.1093/biolre/ioy057. 2018
Extracellular Matrix Hydrogels from Decellularized Endometrium Promote Tissue Regeneration and Fertility Restoration in a Murine Model of Endometrial Damage.
Lopez-Martinez, S; (...); Cervello, I
Meeting Abstract. 2021
EXTRACELLULAR VESICLES SECRETED BY ENDOMETRIAL ORGANOIDS FROM ADENOMYOSIS PATIENTS CONTAIN MIRNAS IMPLICATED IN DISEASE DEVELOPMENT, EMBRYO IMPLANTATION FAILURE AND PREGNANCY DISORDERS
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Future Challenges and Opportunities of Extracellular Matrix Hydrogels in Female Reproductive Medicine
Francés-Herrero E; (...); Cervelló I
Article. 10.3390/ijms23073765. 2022
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/beta-catenin and TGF-beta pathways.
Carbajo-García MC; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01060-2. 2023
Histone deacetylase inhibition by suberoylanilide hydroxamic acid: a therapeutic approach to treat human uterine leiomyoma.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1016/j.fertnstert.2021.10.012. 2022
Human Adenomyosis Endometrial Organoids Recapitulate Disease Pathological Features and Show Dysregulated Expression of Implantation and Placentation Biomarkers
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation.
Segura-Benítez M; (...); Ferrero H
Article. 10.1093/humrep/dead138. 2023
HUMAN BLASTOCYSTS UPTAKE EXTRACELLULAR VESICLES SECRETED BY PRIMARY ENDOMETRIAL EPITHELIAL CELLS CONTAINING MIRNAS RELATED TO IMPLANTATION AND EARLY EMBRYO DEVELOPMENT
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Human Platelet-Rich Plasma from Adult Peripheral and Umbilical Cord Blood: Endometrial Regeneration and Proteomic Profiles in a Murine Model of Asherman Syndrome.
de Miguel-Gomez, L; (...); Cervello, I
Meeting Abstract. 2020
Human Umbilical Cord-Based Therapeutics: Stem Cells and Blood Derivatives for Female Reproductive Medicine
Rodriguez-Eguren, Adolfo; (...); Cervello, Irene
Review. 10.3390/ijms232415942. 2022
Hybrid Endometrial-Derived Hydrogels: Human Organoid Culture Models and In Vivo Perspectives.
Gomez-alvarez, Maria; (...); Cervello, Irene
Article. 10.1002/adhm.202303838. 2023
Improved Models of Human Endometrial Organoids Based on Hydrogels from Decellularized Endometrium
Frances-Herrero, Emilio; (...); Cervello, Irene
Article. 10.3390/jpm11060504. 2021
In Pursuit of the Optimal Hydrogel for Follicle Culture: An In-depth Comparison of Ovarian Decellularization Protocols.
Campo, H; (...); Cervello, I
Meeting Abstract. 2020
Inhibition of cell proliferation and extracellular matrix formation in human uterine leiomyomas by 5-aza-2 '-deoxycitidine via Wnt/beta-catenin pathway
Carbajo-Garcia, MC; (...); Ferrero, H
Meeting Abstract. 2021
Inhibition of tumor cell proliferation in human uterine leiomyomas by vitamin D via Wnt/ß-catenin pathway.
Corachán A; (...); Pellicer A
Article. 10.1016/j.fertnstert.2018.10.008. 2019
Integrative analysis of the DNA methylome and transcriptome in uterine leiomyoma shows altered regulation of genes involved in metabolism, proliferation, extracellular matrix and vesicles.
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Article. 10.1002/path.5920. 2022
Long-term vitamin D treatment decreases human uterine leiomyoma size in a xenograft animal model.
Corachán A; (...); Pellicer A
Article. 10.1016/j.fertnstert.2019.09.018. 2020
Metformin Treatment Decreases Clinical Miscarriage and Improves Live Birth Rates in Infertile Patients with Insulin Resistance.
Belen Albert, Ana; (...); Ferrero, Hortensia
Meeting Abstract. 2024
Microphysiological Modeling of the Human Endometrium
Campo H; (...); Kim JJ
Article. 10.1089/ten.tea.2020.0022. 2020
New insights for fertility preservation by ovarian tissue cryopreservation and transplantation in pediatric cancer patients.
Editorial Material. 10.1016/j.fertnstert.2020.07.057. 2020
Next Generation of Human Endometrial Organoids: Bioengineering-Based Strategies for Preserving Tissue-Specific Extracellular Environment.
Frances-Herrero, E; (...); Cervello, I
Meeting Abstract. 2021
Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects.
Corachán A; (...); Ferrero H
Article. 10.1093/humupd/dmab014. 2021
Personalized medicine through three-dimensional cell-based culture systems in assisted reproductive technologies: How close are we?
Editorial Material. 10.1016/j.fertnstert.2020.07.021. 2020
Potential Role of Nervous System Related Functions in Uterine Leiomyoma Pathogenesis
Carbajo-Garcia, Maria Cristina; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Proteomic Analysis of Extracellular Vesicles Secreted by Primary Endometrial Epithelial Cells from Fertile Women Reveals Functions Related to Embryo Implantation Not Present in an Endometrial Epithelial Cell Line.
Segura-Benitez, M; (...); Ferrero, H
Meeting Abstract. 2021
Proteomic analysis of extracellular vesicles secreted by primary human epithelial endometrial cells reveals key proteins related to embryo implantation.
Segura-Benitez, Marina; (...); Ferrero, Hortensia
Article. 10.1186/s12958-021-00879-x. 2022
Reply: Bone marrow-derived endometrial cells: what you see is what you get
Santamaria, X; (...); Simon, C
Letter. 10.1093/humupd/dmy042. 2019
Role of Endometrial Extracellular Vesicles miRNAs as Potential Autocrine Regulators of Gene Expression During Embryo Implantation Process in Adenomyosis.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2024
Stem cell paracrine actions in tissue regeneration and its potential therapeutic effect in human endometrium: a retrospective study.
de Miguel-Gómez L; (...); Cervelló I
Article. 10.1111/1471-0528.16078. 2020
Stem cell secreted factor therapy regenerates the ovarian niche and rescues follicles.
Buigues, Anna; (...); Herraiz, Sonia
Article. 10.1016/j.ajog.2021.01.023. 2021
Stem cell therapy induces a shift from an inflammatory environment towards an immune tolerant scenario promoting endometrial tissue regeneration
De Miguel-Gomez, L.; (...); Cervello, I.
Meeting Abstract. 2019
Stem Cells and the Endometrium: From the Discovery of Adult Stem Cells to Pre-Clinical Models
de Miguel-Gómez L; (...); Cervelló I
Review. 10.3390/cells10030595. 2021
Strategies for managing asherman's syndrome and endometrial atrophy: Since the classical experimental models to the new bioengineering approach
de Miguel-Gómez L; (...); Cervelló I
Review. 10.1002/mrd.23523. 2021
THE TIMING OF PROGESTERONE CORRECTED AFTER ENDOMETRIAL TRANSCRIPTOMI( ANALYSIS DI)ES NOT IMPROVE REPRODUCTIVE OUTCOME IN WOMEN WITH ADENGJD TOMS AND NON -RECEPTIVE ENDONIETRIUM
Cozzolino, Mauro; (...); Ferrero, Hortensia
Meeting Abstract. 2022
Towards the Development of the Bioengineered Ovary: Comparative Proteomic Analysis of Different Extracellular Matrix Hydrogels.
Campo, H; (...); Cervello, I
Meeting Abstract. 2021
Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders.
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Article. 10.1186/s12958-023-01182-7. 2024
Transcriptomic Analysis of Adenomyosis Mid-Secretory Endometrial Organoids Reveals Deregulated Molecular Mechanisms Involved in Implantation Failure and Pregnancy Loss
Juarez-Barber, Elena; (...); Ferrero, Hortensia
Meeting Abstract. 2023
Undetectable viral RNA from SARS-CoV-2 in endometrial biopsies from women with COVID-19: a preliminary study.
de Miguel-Gómez L; (...); Cervelló I
Letter. 10.1016/j.ajog.2021.10.019. 2021
UNVEILING ENDOMETRIOSIS: TRANSCRIPTOMIC PROFILING REVEALS MOLECULAR DYSREGULATION IN GESTATIONAL ENDOMETRIAL ORGANOIDS.
Bas-Rivas, Alba; (...); Ferrero, Hortensia
Meeting Abstract. 10.1016/j.fertnstert.2024.07.589. 2024
Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation.
Corachán A; (...); Ferrero H
Article. 10.1016/j.fertnstert.2020.07.049. 2020
Vitamin D as an effective treatment to reduce cell proliferation and extracellular matrix formation in human uterine leiomyomas regardless MED12 mutation status
Corachan, A; (...); Ferrero, H
Meeting Abstract. 2020
VITAMIN D LONG-TERM TREATMENT DECREASES HUMAN UTERINE LEIOMYOMA SIZE THROUGH SPECIFIC MOLECULAR MECHANISMS IN A XENOGRAFT ANIMAL MODEL.
Corachan, A; (...); Pellicer, A
Meeting Abstract. 10.1016/j.fertnstert.2019.07.347. 2019