Portal de investigación
Estrategia terapéutica contra la enfermedad de Huntington mediante la activación sinergística de AMPK.
Datos básicos
- Código:
- 2018_0381_CRC_RAMON ARECES_VAZQUEZ
- Protocolo:
- 2018_0381_CRC_RAMON ARECES_VAZQUEZ
- EUDRACT:
- NCT:
- Centro:
- Dotación:
- 129.600,00 €
- Año de incio:
- 2019
- Año de finalización:
- 2022
Objetivos del proyecto
Código Proyecto organismo: CIVP19S8119.
Documentos
- No hay documentos
Participantes
Grupos
Financiadores - Promotores
Resultados del Ensayo Clínico
A predictive model for prostate cancer incorporating PSA molecular forms and age.
Oto J; (...); Navarro S
Article. 10.1038/s41598-020-58836-4. 2020
Activated protein C assays: a review.
Review. 10.1016/j.cca.2019.11.005. 2020
Apparent Radiological Improvement in an Infant With Labrune Syndrome Treated With Bevacizumab
Martinez-Matilla, Marina; (...); Pedrola, Laia
Letter. 10.1016/j.pediatrneurol.2020.07.011. 2020
Case report of a trichohepatoenteric syndrome due to heterozygous compound of novel mutations in ttc37 gen
Polo, B.; (...); Cervera, J.
Meeting Abstract. 2019
CRISPR to fix bad blood: a new tool in basic and clinical hematology
Gonzalez-Romero, E; (...); Sanjuan-Pla, A
Review. 10.3324/haematol.2018.211359. 2019
CRISPR-Cas9 editing of a TNPO3 mutation in a muscle cell model of limb-girdle muscular dystrophy type D2.
Poyatos-Garcia, Javier; (...); Vilchez, Juan Jesus
Article. 10.1016/j.omtn.2023.01.004. 2023
Changes in lipid metabolism driven by steroid signalling modulate proteostasis in C. elegans.
Gomez-Escribano, Ana P.; (...); Vazquez-Manrique, Rafael P.
Article. 10.15252/embr.202255556. 2023
Changes in sleep-disordered breathing from the acute to the stable phase of pulmonary embolism and impact of right ventricular dysfunction: preliminary findings of ESAET study
Ortega, AG; (...); Martinez-Garcia, MA
Meeting Abstract. 10.1183/13993003.congress-2020.4974. 2020
Characterization of RAN Translation and Antisense Transcription in Primary Cell Cultures of Patients with Myotonic Dystrophy Type 1.
Koehorst, Emma; (...); Nogales-Gadea, Gisela
Article. 10.3390/jcm10235520. 2021
Datopotamab Deruxtecan Vs Docetaxel in Patients with Non-Small Cell Lung Cancer: Final Overall Survival from TROPION-Lung01
Sands, J.; (...); Ahn, M-J
Meeting Abstract. 2024
Deletion of exons 45 to 55 in the DMD gene: from the therapeutic perspective to the in vitro model
Poyatos-Garcia, Javier; (...); Vilchez, Juan J
Article. 10.1186/s13395-024-00353-3. 2024
Docosahexaenoic Acid (DHA) Supplementation in a Triglyceride Form Prevents from Polyglutamine-Induced Dysfunctions in Caenorhabditis elegans
Mora, Ignasi; (...); Arola, Lluis
Article. 10.3390/ijms252312594. 2024
Dystrophinopathic subjects with a specific mega-deletion of exons 45-55 in the DMD gene, as a template for CRISPR/Cas9 therapy in Duchenne muscular dystrophy
Poyatos-Garcia, J; (...); Vilchez, J
Meeting Abstract. 10.1016/j.nmd.2019.06.404. 2019
Erucin, a Natural Isothiocyanate, Prevents Polyglutamine-Induced Toxicity in Caenorhabditis elegans via aak-2/AMPK and daf-16/FOXO Signaling
Balducci, Martina; (...); Tarozzi, Andrea
Article. 10.3390/ijms252212220. 2024
Great clinical variability of Nance Horan syndrome due to deleterious NHS mutations in two unrelated Spanish families.
Hernández V; (...); Pedrola L
Article. 10.1080/13816810.2019.1692362. 2019
Hidden etiology of cerebral palsy: genetic and clinical heterogeneity and efficient diagnosis by next-generation sequencing.
Rosello M; (...); Tomás M
Review. 10.1038/s41390-020-01250-3. 2020
IDENTIFICATION OF 58 MUTATIONS (26 NEW) IN 94 OF 109 BEING TESTED WITH PROTEIN DEFICIENCY C. SETH WORKING GROUP
Fernandez-Pardo, A.; (...); Navarro, S.
Meeting Abstract. 2019
Identification of 58 Mutations (26 Novel) in 94 of 109 Symptomatic Spanish Probands with Protein C Deficiency
Martos, L; (...); Spanish Soc Thrombosis Haemostasis
Article. 10.1055/s-0039-1692440. 2019
IDENTIFICATION OF A PROFILE OF CLASSES OF CIRCULATING LIPIDS ASSOCIATED WITH THE VENOUS THROMBOEMBOLISM
Fernandez-Pardo, A.; (...); Navarro, S.
Meeting Abstract. 2019
Identification of Novel microRNA Profiles Dysregulated in Plasma and Tissue of Abdominal Aortic Aneurysm Patients
Plana E; (...); Miralles M
Article. 10.3390/ijms21134600. 2020
Increase of Neutrophil Activation Markers in Venous Thrombosis-Contribution of Circulating Activated Protein C
Martos L; (...); Medina P
Article. 10.3390/ijms21165651. 2020
INSM1 immunohistochemical expression in a large cohort of Ewing sarcoma family of tumours
Llombart-Bosch, A; (...); Picci, P
Meeting Abstract. 2019
Loss of glutathione redox homeostasis impairs proteostasis by inhibiting autophagy-dependent protein degradation
Guerrero-Gomez, D; (...); Miranda-Vizuete, A
Article. 10.1038/s41418-018-0270-9. 2019
Metformin to treat Huntington disease: a pleiotropic drug against a multi-system disorder.
Trujillo-Del Río C; (...); Vázquez-Manrique RP
Article. 10.1016/j.mad.2022.111670. 2022
Metformin treatment reduces motor and neuropsychiatric phenotypes in the zQ175 mouse model of Huntington disease
Sanchis, A; (...); Vazquez-Manrique, RP
Article. 10.1038/s12276-019-0264-9. 2019
microRNAs and Markers of Neutrophil Activation as Predictors of Early Incidental Post-Surgical Pulmonary Embolism in Patients with Intracranial Tumors
Article. 10.3390/cancers12061536. 2020
MicroRNAs and Neutrophil Activation Markers Predict Venous Thrombosis in Pancreatic Ductal Adenocarcinoma and Distal Extrahepatic Cholangiocarcinoma.
Article. 10.3390/ijms21030840. 2020
miRNAs and Genes Involved in the Interplay between Ocular Hypertension and Primary Open-Angle Glaucoma. Oxidative Stress, Inflammation, and Apoptosis Networks
Raga-Cervera, J; (...); Zanon-Moreno, V
Article. 10.3390/jcm10112227. 2021
Mn(II) Quinoline Complex (4QMn) Restores Proteostasis and Reduces Toxicity in Experimental Models of Huntington's Disease
Merino, Marian; (...); Mullor, Jose L.
Article. 10.3390/ijms23168936. 2022
MODELING OF IDH2 GENE MUTATIONS IN THE CAENORHABDITIS ELEGANS ORGANISM. DEVELOPMENT OF A NEW STUDY MODEL
Gonzalez-Romero, E.; (...); Cervera-Zamora, J.
Meeting Abstract. 2021
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2 Caused by a Novel PIGA Variant Not Associated with a Skewed X-Inactivation Pattern
Gabaldon-Albero, Alba; (...); Martinez, Francisco
Article. 10.3390/genes15060802. 2024
Multiview motion tracking based on a cartesian robot to monitor Caenorhabditis elegans in standard Petri dishes.
Puchalt JC; (...); Sanchez-Salmeron, Antonio-Jose
Article. 10.1038/s41598-022-05823-6. 2022
Neuroprotective Effect of IND1316, an Indole-Based AMPK Activator, in Animal Models of Huntington Disease.
Vela, Marta; (...); Castro, Ana
Article. 10.1021/acschemneuro.1c00758. 2022
Novel nonclassic progesterone receptor PGRMC1 pulldown-precipitated proteins reveal a key role during human decidualization
Salsano, S; (...); Dominguez, F
Article. 10.1016/j.fertnstert.2020.01.008. 2020
Pancreatic Malformation and Heterotaxy Syndrome Associated With 6q25.1 Haploinsufficiency.
Sufrate-Vergara, Berta; (...); Rodriguez-Lopez, Raquel
Article. 10.1097/MPA.0000000000002473. 2025
PCR-Based Strategy for Introducing CRISPR/Cas9 Machinery into Hematopoietic Cell Lines.
González-Romero E; (...); Vázquez-Manrique RP
Article. 10.3390/cancers15174263. 2023
PLASMATIC DNA STIMULATES THE GENERATION OF IN VITRO THROMBIN EVEN IN THE ABSENCE OF EXTRINSIC TISSUE FACTOR AND CAN BE REVERSED WITH DNA'S
Fernandez-Pardo, A.; (...); Medina, P.
Meeting Abstract. 2019
Reactive Species in Huntington Disease: Are They Really the Radicals You Want to Catch?
Bono-Yagüe J; (...); Vázquez-Manrique RP
Review. 10.3390/antiox9070577. 2020
SJOGREN-LARSSON SYNDROME IN TWO SISTERS WITH AN INTRONIC VARIANT OF ALDH3A2 GENE: CLINICAL FINDINGS
Fernandez, F.; (...); Cervera, J.
Meeting Abstract. 2019
Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans.
Mora I; (...); Puiggròs F
Article. 10.3390/cells12151932. 2023
Synergistic activation of AMPK prevents from polyglutamine-induced toxicity in Caenorhabditis elegans.
Gómez-Escribano AP; (...); Vázquez-Manrique RP
Article. 10.1016/j.phrs.2020.105105. 2020
The Female Sexual Function Index to assess patients with moderate to severe vulvar lichen sclerosus.
Gutierrez-Ontalvilla P; (...); Vicente D
Letter. 10.1684/ejd.2019.3580. 2019
TRANSCRIPTOMICAL ANALYSIS AND MODELING IN C.ELEGANS OF THE IDH2 R140 R172 MUTATION
Gonzalez-Romero, E.; (...); Cervera-Zamora, J., V
Meeting Abstract. 2019
Urinary microRNAs: Looking for a New Tool in Diagnosis, Prognosis, and Monitoring of Renal Cancer
Article. 10.1007/s11934-020-0962-9. 2020
Urine metabolomic analysis in clear cell and papillary renal cell carcinoma: A pilot study
Article. 10.1016/j.jprot.2020.103723. 2020
Utility of Optical Genome Mapping for Accurate Detection and Fine-Mapping of Structural Variants in Elusive Rare Diseases
Orellana, Carmen; (...); Martinez, Francisco
Article. 10.3390/ijms26031244. 2025
VALIDATION OF A MODEL WITH COAGULATION-RELATED MARKERS FOR THE DIAGNOSIS OF PROSTHETIC JOINT INFECTION
Oto, J.; (...); Medina, P.
Meeting Abstract. 2019
Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma
Burgos-Panadero, R; (...); Noguera, R
Article. 10.1186/s12885-019-5693-2. 2019