Valor de la expresion inmunohistoquimica de alfa-metilacil-CoA racemasa en la progresion del carcinoma de colon.

Autores de IIS La Fe

• Jessica Valdivia García

  Autor

• Empar Mayordomo Aranda

  Autor

• David Hervás Marín

  Autor

• David Ramos Escorihuela

  Autor

Participantes ajenos a IIS La Fe

• Gonzalez-Matea M

Abstract

Alpha-methylacyl-CoA racemase (AMACR) expression has been demonstrated in several normal tissues and in diverse types of carcinoma. Our aim was to analyze the immunohistochemical expression of AMACR in the sequence-progression of colonic cancer. We studied 237 cases, including samples of normal mucosa of the colon, adenomas with different degrees of dysplasia, colonic carcinomas, lymph nodes and liver metastases of colonic carcinomas. A scale of intensity and percentage of expression was used to analyze the AMACR immunohistochemical profile. The expression was nearly absent in samples of normal mucosa, increased in both adenomas and carcinomas, decreased in lymph node metastases but was significantly increased in liver metastases.

Keywords

• *AMACR; *Carcinoma de colon; *Colonic carcinoma; *Immunohistochemistry; *Inmunohistoquimica; *P504S; *Racemasa; *Racemase