Portal de investigación
Involvement of leucocyte/endothelial cell interactions in anorexia nervosa
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Victor VM
- Rovira-Llopis S
- Banuls C
- de Pablo C
- Alvarez A
- Rocha M
- Hernandez-Mijares A
Abstract
BackgroundAnorexia nervosa is a common psychiatric disorder in adolescence and is related to cardiovascular complications. Our aim was to study the effect of anorexia nervosa on metabolic parameters, leucocyte-endothelium interactions, adhesion molecules and proinflammatory cytokines. Materials and MethodsThis multicentre, cross-sectional, case-control study employed a population of 24 anorexic female patients and 36 controls. We evaluated anthropometric and metabolic parameters, interactions between leucocytes polymorphonuclear neutrophils (PMN) and human umbilical vein endothelial cells (HUVEC), proinflammatory cytokines such as tumour necrosis factor alpha (TNF-) and interleukin-6 (IL-6) and soluble cellular adhesion molecules (CAMs) including E-selectin, vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1). ResultsAnorexia nervosa was related to a decrease in weight, body mass index, waist circumference, systolic blood pressure, glucose, insulin and HOMA-IR, and an increase in HDL cholesterol. These effects disappeared after adjusting for BMI. Anorexia nervosa induced a decrease in PMN rolling velocity and an increase in PMN rolling flux and PMN adhesion. Increases in IL-6 and TNF- and adhesion molecule VCAM-1 were also observed. ConclusionsThis study supports the hypothesis of an association between anorexia nervosa, inflammation and the induction of leucocyte-endothelium interactions. These findings may explain, in part at least, the increased risk of vascular disease among patients with anorexia nervosa.
Datos de la publicación
- ISSN/ISSNe:
- 0014-2972, 1365-2362
- Tipo:
- Article
- Páginas:
- 670-678
- DOI:
- 10.1111/eci.12454
- PubMed:
- 25944525
- Factor de Impacto:
- 1,232 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION WILEY
Citas Recibidas en Web of Science: 17
Documentos
- No hay documentos
Filiaciones
Keywords
- Adhesion; anorexia; cytokines; leucocytes; endothelium interaction; lipid profile
Campos de Estudio
Cita
Victor VM,Rovira S,SAIZ V,SANGUESA MC,ROJO L,Banuls C,de Pablo C,Alvarez A,ROJO L,Rocha M,Hernandez A. Involvement of leucocyte/endothelial cell interactions in anorexia nervosa. Eur. J. Clin. Invest. 2015. 45. (7):p. 670-678. IF:2,687. (1).