Lower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance

Fecha de publicación: 01/05/2016

Autores de IIS La Fe

Ángel Alberich Bayarri

Autor

Participantes ajenos a IIS La Fe

Puig J
Blasco G
Daunis-i-Estadella J
Moreno M
Molina X
Xifra G
Pedraza S
Ricart W
Fernandez-Aranda F
Fernandez-Real JM

Grupos

Investigacion Biomédica en Imagen (GIBI 2-30)

Investigador Principal

Leonor Cerdá Alberich

Abstract

ObjectiveRodent models have found that osteocalcin crosses the blood-brain barrier and regulates behaviour. No data are available on osteocalcin's effects on brain microstructure and cognitive performance in humans. We evaluated the association between serum osteocalcin concentrations and (i) brain microstructural changes on magnetic resonance imaging (MRI) and (ii) neuropsychological performance. Design, Patients and MeasurementsWe studied 24 consecutive obese subjects (13 women; age, 498 81 years; body mass index [BMI], 439 454 kg/m(2)) and 20 healthy volunteers (10 women; age, 488 +/- 95 years; BMI, 243 +/- 354 kg/m(2)) in a cross-sectional study within the multicentre FLORINASH Project. FLAIR signal intensity and DTI-metrics (primary ((1)), secondary ((2)) and tertiary ((3)) eigenvalues; fractional anisotropy (FA); and mean diffusivity) in the caudate, hypothalamus, thalamus and putamen, and in subcortical white matter were assessed. Cognitive performance evaluated by neuropsychological test battery. ResultsLower osteocalcin concentrations were associated with BMI, higher (1,) (2) and (3) values at the caudate and lower FLAIR signal intensity at the caudate and putamen. Obese patients with lower osteocalcin concentrations had higher FA at putamen and thalamus. Lower osteocalcin concentrations were associated with higher Iowa Gambling Task (IGT) scores. FLAIR signal intensity at the caudate <601832 yielded 857% sensitivity, 643% specificity, 706% negative predictive value and 818% positive predictive value for IGT score. Lower osteocalcin was an independent predictor of worse cognitive performance on multivariate analysis (F = 3551, P = 001343; R-2 = 0103). Bayesian information criterion demonstrated that osteocalcin had the predominant role in predicting IGT score. ConclusionsLower serum osteocalcin concentrations are associated with brain microstructural changes and worse cognitive performance.

Datos de la publicación

ISSN/ISSNe:: 0300-0664, 1365-2265
Tipo:: Article
Páginas:: 756-763
DOI:: 10.1111/cen.12954
PubMed:: 26406918
Factor de Impacto:: 1,345 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Puig J:: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain

Department of Computer Science, Applied Mathematics and Statistics, University of Girona, Girona, Spain
Blasco G:: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
Daunis-i-Estadella J:: Department of Computer Science, Applied Mathematics and Statistics, University of Girona, Girona, Spain
Moreno M:: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain
Molina X:: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
Alberich-Bayarri A:: Instituto de Investigación. Biomedical Imaging Research Group (GIBI230), La Fe Polytechnics and University Hospital, La Fe Health Research Institute, Valencia, Spain
Xifra G:: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain
Pedraza S:: Department of Radiology (IDI), Research Unit, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, Girona, Spain
Ricart W:: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain
Fernandez-Aranda F:: Department of Psychiatry, Hospital Universitari de Bellvitge, and CIBER Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Barcelona, Spain
Fernandez-Real JM:: Department of Diabetes, Endocrinology and Nutrition, Girona Biomedical Research Institute (IDIBGI), Hospital Universitari de Girona Dr Josep Trueta, and CIBER Fisiopatología de la Obesidad y Nutrición (CIBERobn), Girona, Spain

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