High-resolution blood-pool-contrast-enhanced MR angiography in glioblastoma: tumor-associated neovascularization as a biomarker for patient survival. A preliminary study

Fecha de publicación: 01/01/2016

Autores de IIS La Fe

Ángel Alberich Bayarri

Autor

Participantes ajenos a IIS La Fe

Puig J
Blasco G
Daunis-I-Estadella J
Essig M
Jain R
Remollo S
Hernandez D
Puigdemont M
Sanchez-Gonzalez J
Mateu G
Wintermark M
Pedraza S

Grupos

Investigacion Biomédica en Imagen (GIBI 2-30)

Investigador Principal

Leonor Cerdá Alberich

Abstract

The objective of the study was to determine whether tumor-associated neovascularization on high-resolution gadofosveset-enhanced magnetic resonance angiography (MRA) is a useful biomarker for predicting survival in patients with newly diagnosed glioblastomas. Before treatment, 35 patients (25 men; mean age, 64 +/- 14 years) with glioblastoma underwent MRI including first-pass dynamic susceptibility contrast (DSC) perfusion and post-contrast T1WI sequences with gadobutrol (0.1 mmol/kg) and, 48 h later, high-resolution MRA with gadofosveset (0.03 mmol/kg). Volumes of interest for contrast-enhancing lesion (CEL), non-CEL, and contralateral normal-appearing white matter were obtained, and DSC perfusion and DWI parameters were evaluated. Prognostic factors were assessed by Kaplan-Meier survival and Cox proportional hazards model. Eighteen (51.42 %) glioblastomas were hypervascular on high-resolution MRA. Hypervascular glioblastomas were associated with higher CEL volume and lower Karnofsky score. Median survival rates for patients with hypovascular and hypervascular glioblastomas treated with surgery, radiotherapy, and chemotherapy were 15 and 9.75 months, respectively (P < 0.001). Tumor-associated neovascularization was the best predictor of survival at 5.25 months (AUC = 0.794, 81.2 % sensitivity, 77.8 % specificity, 76.5 % positive predictive value, 82.4 % negative predictive value) and yielded the highest hazard ratio (P < 0.001). Tumor-associated neovascularization detected on high-resolution blood-pool-contrast-enhanced MRA of newly diagnosed glioblastoma seems to be a useful biomarker that correlates with worse survival.

Datos de la publicación

ISSN/ISSNe:: 0028-3940, 1432-1920
Tipo:: Article
Páginas:: 17-26
DOI:: 10.1007/s00234-015-1599-0
PubMed:: 26438560
Factor de Impacto:: 1,044 SCImago ℠
Cuartil:: Q1 SCImago ℠

Documentos

No hay documentos

Métricas

Filiaciones

Puig J:: Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology [Girona Biomedical Research Institute] IDIBGI, Hospital Universitari Dr Josep Trueta, Av de Francia s/n, 17007, Girona, Spain.
Blasco G:: Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology [Girona Biomedical Research Institute] IDIBGI, Hospital Universitari Dr Josep Trueta, Av de Francia s/n, 17007, Girona, Spain
Daunis-I-Estadella J:: Department of Computer Science, Applied Mathematics and Statistics, University of Girona, Girona, Spain
Alberich-Bayarri A:: Instituto de Investigación. Biomedical Imaging Research Group (GIBI230), La Fe Health Research Institute, La Fe Polytechnics and University Hospital, Valencia, Spain
Essig M:: Department of Radiology, University of Manitoba, Winnipeg, Canada
Jain R:: Division of Neuroradiology, Department of Radiology, NYU School of Medicine, New York, NY, USA
Remollo S:: Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology [Girona Biomedical Research Institute] IDIBGI, Hospital Universitari Dr Josep Trueta, Av de Francia s/n, 17007, Girona, Spain
Hernandez D:: Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology [Girona Biomedical Research Institute] IDIBGI, Hospital Universitari Dr Josep Trueta, Av de Francia s/n, 17007, Girona, Spain
Puigdemont M:: Catalan Institute of Oncology (ICO), Hospital Cancer Registry, Hospital Universitari Dr Josep Trueta, Girona, Spain
Sanchez-Gonzalez J:: Philips Healthcare Iberica, Madrid, Spain
Mateu G:: Department of Computer Science, Applied Mathematics and Statistics, University of Girona, Girona, Spain
Wintermark M:: Department of Radiology, Neuroradiology Division, Stanford University, Palo Alto, CA, USA
Pedraza S:: Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology [Girona Biomedical Research Institute] IDIBGI, Hospital Universitari Dr Josep Trueta, Av de Francia s/n, 17007, Girona, Spain

Keywords

Brain neoplasms; Glioblastoma; Magnetic resonance imaging; Angiography; Survival

Proyectos y Estudios Clínicos

PATRONES DE RM CEREBRAL Y MEDULAR EN RELACION CON LA PRESENCIA DE AUTOANTIGENOS NEURONALES RECONOCIDOS POR INMUNOGLOBULINAS M PRESENTES EN EL LIQUIDO CEFALORRAQUIDEO DE PACIENTES DE ESCLEROSIS MULTIPLE.

Investigador Principal: ISABEL BOSCÁ BLASCO

MERCK SERONO DR. CASANOVA . ALMIRALL S.A; FUNDACIÓN BIOGEN IDEC; MERCK S.L.U; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

CONTROL Y SEGUIMIENTO INTEGRAL DE LA RADIACIÓN IONIZANTE RECIBIDA TRAS EXPLORACIONES MÉDICAS: COSIRI.

Investigador Principal: ÁNGEL ALBERICH BAYARRI

GV/2015/132 . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; CONSELLERIA DE EDUCACION . 2015

PREMICAT. DESARROLO DE UNA ESTRATEGIA PARA LA PREVENCION MIOCARDICA DEL DAÑO INDUCIDO POR REPERFUSION BASADA EN EL USO DE CATETERES Y POLIMEROS TARAPEUTICOS DE NUEVA GENERACION.

Investigador Principal: PILAR SEPÚLVEDA SANCHIS

DTS15/00079 . INSTITUTO DE SALUD CARLOS III . 2016

TERAPIA CELULAR DESPUES DEL ICTUS DIRIGIDA MEDIANTE CAMPOS MAGNETICOS. APLICACION DE RM-TDI Y TRACTOGRAFIA CEREBRAL EN ICTUS PARA LA VALORACION DEL DAÑO NEUROLOGICO

Investigador Principal: JOSÉ MANUEL GARCÍA VERDUGO

2015_0534_GARCIA_VERDUGO_MAPFRE . 2015

DISEÑO Y DESARROLLO DE UNA PLATAFORMA MULTIESCALA-IN VITRO-IN VIVO PARA LA PREVENCIÓN DE LA FRACTURA ÓSEA OSTEOPORÓTICA MEDIANTE CEMENTACIÓN FEMORAL: UNA HERRAMIENTA PRECLÍNICA