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Epigenetic control of influenza virus: role of H3K79 methylation in interferon-induced antiviral response
Data de publicació:
Autors de IIS La Fe
Autors aliens a IIS La Fe
- Marcos-Villar, L
- Diaz-Colunga, J
- Zamarreno, N
- Landeras-Bueno, S
- Esteller, M
- Falcon, A
- Nieto, A
Grups d'Investigació
Abstract
Influenza virus stablishes a network of virus-host functional interactions, which depends on chromatin dynamic and therefore on epigenetic modifications. Using an unbiased search, we analyzed the epigenetic changes at DNA methylation and post-translational histone modification levels induced by the infection. DNA methylation was unaltered, while we found a general decrease on histone acetylation, which correlates with transcriptional inactivation and may cooperate with the impairment of cellular transcription that causes influenza virus infection. A particular increase in H3K79 methylation was observed and the use of an inhibitor of the specific H3K79 methylase, Dot1L enzyme, or its silencing, increased influenza virus replication. The antiviral response was reduced in conditions of Dot1L downregulation, since decreased nuclear translocation of NF-kB complex, and IFN-beta, Mx1 and ISG56 expression was detected. The data suggested a control of antiviral signaling by methylation of H3K79 and consequently, influenza virus replication was unaffected in IFN pathway-compromised, Dot1L-inhibited cells. H3K79 methylation also controlled replication of another potent interferon-inducing virus such as vesicular stomatitis virus, but did not modify amplification of respiratory syncytial virus that poorly induces interferon signaling. Epigenetic methylation of H3K79 might have an important role in controlling interferon-induced signaling against viral pathogens.
Dades de la publicació
- ISSN/ISSNe:
- 2045-2322, 2045-2322
- Tipus:
- Article
- Pàgines:
- 1230-1230
- PubMed:
- 29352168
- Factor d'Impacte:
- 1,414 SCImago ℠
- Quartil:
- Q1 SCImago ℠
SCIENTIFIC REPORTS NATURE PUBLISHING GROUP
Cites Rebudes en Web of Science: 32
Documents
- No hi ha documents
Filiacions
Keywords
- NF-KAPPA-B; RNA-POLYMERASE-II; GENE-EXPRESSION; HISTONE MODIFICATIONS; CHROMATIN REMODELER; DNA METHYLATION; PA SUBUNIT; IN-VITRO; A VIRUS; RIG-I
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