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Functional Magnetic Mesoporous Silica Microparticles Capped with an Azo-Derivative: A Promising Colon Drug Delivery Device

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Teruel, AH
  • Coll, C
  • Costero, AM
  • Ferri, D
  • Parra, M
  • Gavina, P
  • Gonzalez-Alvarez, M
  • Merino, V

Grupos

Abstract

Magnetic micro-sized mesoporous silica particles were used for the preparation of a gated material able to release an entrapped cargo in the presence of an azo-reducing agent and, to some extent, at acidic pH. The magnetic mesoporous microparticles were loaded with safranin O and the external surface was functionalized with an azo derivative 1 (bearing a carbamate linkage) yielding solid S1. Aqueous suspensions of S1 at pH 7.4 showed negligible safranin O release due to the presence of the bulky azo derivative attached onto the external surface of the inorganic scaffold. However, in the presence of sodium dithionite (azoreductive agent), a remarkable safranin O delivery was observed. At acidic pH, a certain safranin O release from S1 was also found. The pH-triggered safranin O delivery was ascribed to the acid-induced hydrolysis of the carbamate moiety that linked the bulky azo derivatives onto the mesoporous inorganic magnetic support. The controlled release behavior of S1 was also tested using a model that simulated the gastro intestinal tract.

Datos de la publicación

ISSN/ISSNe:
1420-3049, 1420-3049

MOLECULES  MDPI

Tipo:
Article
Páginas:
-
PubMed:
29439396
Factor de Impacto:
0,757 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 13

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Keywords

  • magnetic mesoporous silica; azo derivatives; pH triggered; azo reductor; colon release

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