Neonatal Outcomes of Very Preterm or Very Low Birth Weight Triplets

Fecha de publicación: 01/12/2018 Fecha Ahead of Print: 21/11/2018

Autores de IIS La Fe

Máximo Vento Torres

Autor

Participantes ajenos a IIS La Fe

Shah, Prakesh S.
Kusuda, Satoshi
Håkansson S
Reichman, Brian
Lui, Kei
Lehtonen, Liisa
Modi, Neena
Adams, Mark
Rusconi, Franca
Norman, Mikael
Darlow, Brian A.
Lodha, Abhay
Yang, Junmin
Bassler, Dirk
Helenius, Kjell K.
Isayama, Tetsuya
Lee, Shoo K.
International Network for Evaluation of Outcomes (iNEO) in Neonates Investigator

Grupos

Perinatología

Leader

Máximo Vento Torres

Abstract

OBJECTIVES: To compare the neonatal outcomes of very preterm triplets with those of matched singletons using a large international cohort. METHODS: A retrospective matched-cohort study of preterm triplets and singletons born between 2007 and 2013 in the International Network for Evaluation of Outcomes in neonates database countries and matched by gestational age, sex, and country of birth was conducted. The primary outcome was a composite of mortality or severe neonatal morbidity (severe neurologic injury, treated retinopathy of prematurity, and bronchopulmonary dysplasia). Unadjusted and adjusted odds ratios with 95% confidence intervals (CIs) were calculated for model 1 (maternal hypertension and birth weight z score) and model 2 (variables in model 1, antenatal steroids, and mode of birth). Models were fitted with generalizing estimating equations and random effects modeling to account for clustering. RESULTS: A total of 6079 triplets of 24 to 32 weeks' gestation or 500 to 1499 g birth weight and 18 232 matched singletons were included. There was no difference in the primary outcome between triplets and singletons (23.4% vs 24.0%, adjusted odds ratio: 0.91, 95% CI: 0.83-1.01 for model 1 and 1.00, 95% CI: 0.90-1.11 for model 2). Rates of severe neonatal morbidities did not differ significantly between triplets and singletons. The results were also similar for a subsample of the cohort (1648 triplets and 4944 matched singletons) born at 24 to 28 weeks' gestation. CONCLUSIONS: No significant differences were identified in mortality or major neonatal morbidities between triplets who were very low birth weight or very preterm and matched singletons.

Datos de la publicación

ISSN/ISSNe:: 0031-4005, 1098-4275
Tipo:: Article
Páginas:: -
DOI:: 10.1542/peds.2018-1938
Factor de Impacto:: 2,996 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Shah, Prakesh S.:: Maternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada

Mt Sinai Hosp, Dept Pediat, 19-231F,600 Univ Ave, Toronto, ON M5G 1X5, Canada

Mt Sinai Hosp, Maternal Infant Care Res Ctr, Toronto, ON, Canada

Univ Toronto, Fac Med, Dept Pediat, Toronto, ON, Canada
Kusuda, Satoshi:: National Research Network Japan, Department of Pediatrics, Kyorin University, Mitaka, Japan

Kyorin Univ, Dept Pediat, Natl Res Network Japan, Mitaka, Tokyo, Japan
Håkansson S:: Swedish Neonatal Quality Register, Unit of Pediatrics, Department of Clinical Science, Umeå University, Umeå, Sweden
Reichman, Brian:: Israel Neonatal Network, Gertner Institute for Epidemiology and Health Policy Research, Tel Hashomer, Israel

Gertner Inst Epidemiol & Hlth Policy Res, Israel Neonatal Network, Tel Hashomer, Israel
Lui, Kei:: Australian and New Zealand Neonatal Network, Department of Newborn Care, Royal Hospital for Women and School of Women's and Children's Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia

Royal Hosp Women, Dept Newborn Care, Australian & New Zealand Neonatal Network, Sydney, NSW, Australia

Univ New South Wales, Fac Med, Sch Womens & Childrens Hlth, Sydney, NSW, Australia
Lehtonen, Liisa:: Department of Pediatrics and Adolescent Medicine, Turku University Hospital and Department of Clinical Medicine, University of Turku, Turku, Finland

Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland

Univ Turku, Dept Clin Med, Turku, Finland
Modi, Neena:: United Kingdom Neonatal Collaborative, Neonatal Data Analysis Unit, Section of Neonatal Medicine, Department of Medicine, Imperial College London and Chelsea and Westminster Hospital, London, United Kingdom

Imperial Coll London, Sect Neonatal Med, Dept Med, Neonatal Collaborat,Neonatal Data Anal Unit, London, England

Chelsea & Westminster Hosp, London, England
Vento, Maximo:: Instituto de Investigación. Spanish Neonatal Network, Health Research Institute La Fe, Avenida Fernando Abril Martorell, Valencia, Spain

Instituto de Investigación. Hlth Res Inst La Fe, Spanish Neonatal Network, Ave Fernando Abril Martorell, Valencia, Spain
Adams, Mark:: Swiss Neonatal Network, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Univ Zurich, Univ Zurich Hosp, Dept Neonatol, Swiss Neonatal Network, Zurich, Switzerland
Rusconi, Franca:: TIN Toscane Online, Unit of Epidemiology, Meyer Children's University Hospital, Regional Health Agency, Florence, Italy

Meyer Childrens Univ Hosp, Reg Hlth Agcy, Epidemiol Unit, TIN Toscane Online, Florence, Italy
Norman, Mikael:: Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden

Department of Neonatal Medicine, Karolinska University Hospital, Stockholm, Sweden

Karolinska Inst, Dept Clin Sci Intervent & Technol, Stockholm, Sweden

Karolinska Univ Hosp, Dept Neonatal Med, Stockholm, Sweden
Darlow, Brian A.:: Department of Paediatrics, University of Otago, Christchurch, Canterbury, New Zealand

Univ Otago, Dept Paediat, Canterbury, New Zealand
Lodha, Abhay:: Departments of Pediatrics and Community Health Sciences, University of Calgary, Calgary, Alberta, Canada

and

Univ Calgary, Dept Pediat, Calgary, AB, Canada

Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada
Yang, Junmin:: Maternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada

Mt Sinai Hosp, Maternal Infant Care Res Ctr, Toronto, ON, Canada
Bassler, Dirk:: Swiss Neonatal Network, Department of Neonatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland

Univ Zurich, Univ Zurich Hosp, Dept Neonatol, Swiss Neonatal Network, Zurich, Switzerland
Helenius, Kjell K.:: Department of Pediatrics and Adolescent Medicine, Turku University Hospital and Department of Clinical Medicine, University of Turku, Turku, Finland

Turku Univ Hosp, Dept Pediat & Adolescent Med, Turku, Finland

Univ Turku, Dept Clin Med, Turku, Finland
Isayama, Tetsuya:: Division of Neonatology, National Center for Child Health and Development, Tokyo, Japan

Natl Ctr Child Hlth & Dev, Div Neonatol, Tokyo, Japan
Lee, Shoo K.:: Maternal-infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada

Obstetrics and Gynecology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada

Mt Sinai Hosp, Dept Pediat, 19-231F,600 Univ Ave, Toronto, ON M5G 1X5, Canada

Mt Sinai Hosp, Maternal Infant Care Res Ctr, Toronto, ON, Canada

Univ Toronto, Fac Med, Dept Pediat, Toronto, ON, Canada

Univ Toronto, Fac Med, Dept Obstet & Gynecol, Toronto, ON, Canada