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Relaxin-2 in Cardiometabolic Diseases: Mechanisms of Action and Future Perspectives

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Feijoo-Bandin, S
  • Aragon-Herrera, A
  • Rodriguez-Penas, D
  • Gonzalez-Juanatey, JR
  • Lago, F

Grupos

Abstract

Despite the great effort of the medical community during the last decades, cardiovascular diseases remain the leading cause of death worldwide, increasing their prevalence every year mainly due to our new way of life. In the last years, the study of new hormones implicated in the regulation of energy metabolism and inflammation has raised a great interest among the scientific community regarding their implications in the development of cardiometabolic diseases. In this review, we will summarize the main actions of relaxin, a pleiotropic hormone that was previously suggested to improve acute heart failure and that participates in both metabolism and inflammation regulation at cardiovascular level, and will discuss its potential as future therapeutic target to prevent/reduce cardiovascular diseases.

Datos de la publicación

ISSN/ISSNe:
1664-042X, 1664-042X

Frontiers in Physiology  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
599-599
PubMed:
28868039
Factor de Impacto:
1,590 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 28

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Keywords

  • cardiovascular diseases; relaxin-2; metabolism; inflammation; therapy; heart

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