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Treatment of Comorbid Alcohol Dependence and Anxiety Disorder: Review of the Scientific evidence and Recommendations for Treatment

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Gimeno, C
  • Dorado, ML
  • Roncero, C
  • Szerman, N
  • Vega, P
  • Alvarez, FJ

Abstract

Patients with alcohol-use disorders (AUDs) have a high prevalence of anxiety disorders (AnxDs). "Co-occurring disorders" refers to the coexistence of an AUD and/or drug related disorders with another non-addictive psychiatric disorder. The aim of this study was to assess the effectiveness of psychopharmacological treatments and psychotherapy in patients with AUD and AnxD and to propose recommendations for the treatment of patients with comorbid AnxDs and AUDs. Randomized clinical trials, meta-analyses, and clinical guidelines were retrieved from PubMed, Embase, and Cochrane databases. Paroxetine was found to be effective in social anxiety patients with alcohol dependence. Selective serotonin reuptake inhibitors (SSRIs), especially sertraline, showed effective results in posttraumatic stress disorder and in comorbid AnxD-AUD. However, SSRIs should be used with caution when patients are actively drinking because they may increase alcohol consumption. Buspirone, gabapentin, and pregabalin were found to be effective in comorbid AnxD-AUD. The treatment of dual AnxDs should start as early as possible. Since AUDs and AnxDs can reinforce each other, treatments targeting both pathologies can be effective. Women suffer from higher levels of stress and AnxDs than men, and they are also more vulnerable to maintaining alcohol consumption levels. Further research is needed in this comorbid patient population, including the study of different types of patients and gender perspectives.

Datos de la publicación

ISSN/ISSNe:
1664-0640, 1664-0640

Frontiers in Psychiatry  FRONTIERS MEDIA SA

Tipo:
Review
Páginas:
173-173
PubMed:
29018367
Factor de Impacto:
1,531 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 35

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Keywords

  • alcohol-use disorder; anxiety disorders; comorbidity; co-occurring disorders; treatment recommendations

Proyectos y Estudios Clínicos

INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.

Investigador Principal: VICENT BALANZA MARTINEZ

PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017

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