Portal de investigación
Active paraplegics are protected against exercise-induced oxidative damage through the induction of antioxidant enzymes
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Ingles, M
- Serra-Ano, P
- Gambini, J
- Dromant, M
- Garcia-Valles, R
- Pareja-Galeano, H
- Garcia-Lucerga, C
- Gomez-Cabrera, MC
Abstract
Study design: Experimental study. Objectives: Exercise improves functional capacity in spinal cord injury (SCI). However, exhaustive exercise, especially when sporadic, is linked to the production of reactive oxygen species that may have a detrimental effect on SCI. We aimed to study the effect of a single bout of exhaustive exercise on systemic oxidative stress parameters and on the expression of antioxidant enzymes in individuals with paraplegia. Setting: The study was conducted in the Physical Therapy department and the Physical Education and Sports department of the University of Valencia. Methods: Sixteen paraplegic subjects were submitted to a graded exercise test (GET) until volitional exhaustion. They were divided into active or non-active groups. Blood samples were drawn immediately, 1 and 2 h after the GET. We determined plasma malondialdehyde (MDA) and protein carbonylation as markers of oxidative damage. Antioxidant gene expression (catalase and glutathione peroxidase-GPx) was determined in peripheral blood mononuclear cells. Results: We found a significant increase in plasma MDA and protein carbonyls immediately after the GET (P<0.05). This increment correlated significantly with the lactate levels. Active paraplegics showed lower levels of exercise-induced oxidative damage (P<0.05) and higher exercise-induced catalase (P<0.01) and GPx (P<0.05) gene expression after the GET. Conclusions: These results suggest that exercise training may be useful in SCI patients to develop systemic antioxidant defenses that may protect them against exercise-induced oxidative damage.
Datos de la publicación
- ISSN/ISSNe:
- 1362-4393, 1476-5624
- Tipo:
- Article
- Páginas:
- 830-837
- DOI:
- 10.1038/sc.2016.5
- PubMed:
- 26882488
- Factor de Impacto:
- 0,851 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
Spinal Cord NATURE PUBLISHING GROUP
Citas Recibidas en Web of Science: 13
Documentos
- No hay documentos
Filiaciones
Keywords
- SPINAL-CORD-INJURY; PHYSICAL-EXERCISE; SUPEROXIDE-DISMUTASE; PERCEIVED EXERTION; WHEELCHAIR USERS; XANTHINE-OXIDASE; OXYGEN-UPTAKE; STRESS; MUSCLE; LYMPHOCYTES
Proyectos y Estudios Clínicos
Cita
Ingles M,Serra P,Gambini J,ABU F,Dromant M,Garcia R,Pareja H,Garcia C,Gomez MC. Active paraplegics are protected against exercise-induced oxidative damage through the induction of antioxidant enzymes. Spinal Cord. 2016. 54. (10):p. 830-837. IF:1,870. (2).