Infectious Complications after Umbilical Cord-Blood Transplantation from Unrelated Donors.

Autors de IIS La Fe

• Jose Montoro Alberola

  Autor

• José Luis Piñana Sánchez

  Autor

• Federico Moscardo Garcia

  Autor

• Jorge Sanz Sánchez

  Autor

Grups d'Investigació

• Cardiopatías familiares, muerte súbita y mecanismos de enfermedad (CAFAMUSME)

  Investigador Principal

  Aitana Braza Boils

Abstract

Umbilical cord-blood (UCB) is a well-recognized alternative source of stem cells for unrelated donor hematopoietic stem cell transplantation (HSCT). As compared with other stem cell sources from adult donors, it has the advantages of immediate availability of cells, absence of risk to the donor and reduced risk of graft-versus-host disease despite donor-recipient HLA disparity. However, the use of UCB is limited by the delayed post-transplant hematologic recovery due, at least in part, to the reduced number of hematopoietic cells in the graft and the delayed or incomplete immune reconstitution. As a result, severe infectious complications continue to be a leading cause of morbidity and mortality following UCB transplantation (UCBT). We will address the complex differences in the immune properties of UCB and review the incidence, characteristics, risk factors, and severity of bacterial, fungal and viral infectious complications in patients undergoing UCBT.