Portal de investigación
Allopurinol partially prevents disuse muscle atrophy in mice and humans
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Ferrando, B
- Gomez-Cabrera, MC
- Salvador-Pascual, A
- Puchades, C
- Derbre, F
- Gratas-Delamarche, A
- Laparre, L
- Olaso-Gonzalez, G
- Cerda, M
- Sebastia, V
- Garcia-Castro, F
- Vina, J
Grupos
Abstract
Disuse muscle wasting will likely affect everyone in his or her lifetime in response to pathologies such as joint immobilization, inactivity or bed rest. There are no good therapies to treat it. We previously found that allopurinol, a drug widely used to treat gout, protects muscle damage after exhaustive exercise and results in functional gains in old individuals. Thus, we decided to test its effect in the prevention of soleus muscle atrophy after two weeks of hindlimb unloading in mice, and lower leg immobilization following ankle sprain in humans (EudraCT: 2011-003541-17). Our results show that allopurinol partially protects against muscle atrophy in both mice and humans. The protective effect of allopurinol is similar to that of resistance exercise which is the best-known way to prevent muscle mass loss in disuse human models. We report that allopurinol protects against the loss of muscle mass by inhibiting the expression of ubiquitin ligases. Our results suggest that the ubiquitin-proteasome pathway is an appropriate therapeutic target to inhibit muscle wasting and emphasizes the role of allopurinol as a non-hormonal intervention to treat disuse muscle atrophy.
Datos de la publicación
- ISSN/ISSNe:
- 2045-2322, 2045-2322
- Tipo:
- Article
- Páginas:
- 3549-3549
- PubMed:
- 29476130
- Factor de Impacto:
- 1,414 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Scientific Reports NATURE PORTFOLIO
Citas Recibidas en Web of Science: 31
Documentos
- No hay documentos
Filiaciones
Keywords
- SKELETAL-MUSCLE; OXIDATIVE STRESS; UBIQUITIN LIGASE; BED REST; CYCLOOXYGENASE-2 EXPRESSION; MOLECULAR-MECHANISMS; PROTEIN-SYNTHESIS; GENE-EXPRESSION; RAT MODEL; KAPPA-B
Campos de Estudio
Cita
Ferrando B,Gomez MC,Salvador A,Puchades C,Derbre F,Gratas A,Laparre L,Olaso G,Cerda M,VIOSCA E,ALABAJOS A,Sebastia V,ALBERICH A,Garcia F,Vina J. Allopurinol partially prevents disuse muscle atrophy in mice and humans. Sci. Rep. 2018. 8. (1):p. 3549-3549. IF:4,011. (1).