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Lung Cancer in Women with a Family History of Cancer: The Spanish Female-specific Database WORLD07

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Isla, D
  • Felip, E
  • Vinolas, N
  • Provencio, M
  • Majem, M
  • Artal, A
  • Bover, I
  • Lianes, P
  • De las Penas, R
  • Catot, S
  • de Castro, J
  • Blasco, A
  • Terrasa, J
  • Gonzalez-Larriba, JL
  • Domine, M
  • Bernabe, R
  • Garrido, P

Grupos

Abstract

Background: The WORLD07 project is a female specific database to prospectively analyze the characteristics of Spanish women with lung cancer. Patients and Methods: We analyzed and compared lung cancer features in women with and without a family history of cancer/lung cancer. Results: Two thousand and sixty women were included: 876 had a family history of cancer (lung cancer, 34%) and 886 did not, with no significant differences between groups, except for smoking status (p=0.036). We found statistically significant correlations between epidermal growth factor receptor (EGFR) mutation and smoking status in patients with a family history of cancer (r=-0.211; p<0.001) and lung cancer (r=-0.176; p<0.001). Longer median overall survival was observed in women with a family history of cancer and lung cancer. Conclusion: Among Spanish women with lung cancer, a greater proportion were current smokers in those with a family history of cancer/lung cancer. There was a significant correlation between the presence of EGFR mutation and smoking.

Datos de la publicación

ISSN/ISSNe:
0250-7005, 1791-7530

ANTICANCER RESEARCH  INT INST ANTICANCER RESEARCH

Tipo:
Article
Páginas:
6647-6653
PubMed:
27919997
Factor de Impacto:
0,769 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 6

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Keywords

  • Cancer; lung cancer risk; Spanish women; family history; WORLD07 database; smoking; epidermal growth factor receptor; menopausal status

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