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Epidemiological characteristics of a Spanish cohort of patients diagnosed with squamous cell carcinoma of head and neck: distribution of risk factors by tumor location

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Seijas-Tamayo, R
  • Fernandez-Mateos, J
  • Klain, JCA
  • Mesia, R
  • Perez-Ruiz, E
  • Fernandez, SV
  • Dominguez, AR
  • Taberna, M
  • Martinez-Trufero, J
  • Abella, TB
  • Estevez, SV
  • Pollan, M
  • Morillo, ED
  • Cruz-Hernandez, JJ

Grupos

Abstract

Head and neck cancer is a highly heterogeneous disease comprising a large number of tumors located in the cervicofacial area. This study aimed to determine the epidemiological characteristics of squamous-cell carcinomas of the head and neck in the Spanish population, and the distribution of risk factors based on tumor locations. A cohort of 459 patients (75 oral cavity, 167 oro-/hypopharyngeal and 217 laryngeal cancers) recruited in 19 hospitals participating in the Spanish head and neck cancer cooperative group were included over 3 years (2012-2014). Epidemiological parameters and risk factors were obtained from a self-administered questionnaire, and tumor characteristics were obtained from clinical records. Multivariate multinomial logistic regression was used to assess factors associated with tumor location. Most patients were males (88.4 %), smokers (95 %) and drinkers (76.5 %). Relative to laryngeal cancer, pharyngeal cancer and oral cancer were more common in women than men (OR 3.58, p = 0.003 and 4.33, p = 0.001, respectively); pharyngeal cancer was more associated with rural environment (OR 1.81, p = 0.007) and weekly alcohol intake (10-140 g: OR 2.53, p = 0.012; 141-280 g: OR 2.47, p = 0.023; > 280 g: OR 3.20, p = 0.001) and less associated with pack-years of smoking (21-40 packs: OR 0.46, p = 0.045; 41-70 packs: OR 0.43, p = 0.023; aeyen71 packs: OR 3.20, p = 0.015). The distribution of these tumors differs between the sexes, with a higher proportion of oral cavity and pharyngeal tumors in women than in men. Oro-/hypopharyngeal cancers were more strongly associated with rural areas and with alcohol consumption, although less strongly associated with smoking than laryngeal tumors.

Datos de la publicación

ISSN/ISSNe:
1699-048X, 1699-3055

Clinical & Translational Oncology  SPRINGER INT PUBL AG

Tipo:
Article
Páginas:
1114-1122
PubMed:
27112939
Factor de Impacto:
0,774 SCImago ℠
Cuartil:
Q2 SCImago ℠

Citas Recibidas en Web of Science: 12

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Keywords

  • Head and neck cancer; Squamous cell carcinoma; Epidemiological characteristics; Spain; Risk factors

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