Portal de investigación
Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Blanco, G
- Puiggros, A
- Baliakas, P
- Athanasiadou, A
- Garcia-Malo, M
- Collado, R
- Xochelli, A
- Rodriguez-Rivera, M
- Ortega, M
- Calasanz, MJ
- Luno, E
- Vargas, M
- Grau, J
- Martinez-Laperche, C
- Valiente, A
- Anagnostopoulos, A
- Gimeno, E
- Abella, E
- Stalika, E
- Hernandez-Rivas, JM
- Ortuno, FJ
- Robles, D
- Ferrer, A
- Ivars, D
- Gonzalez, M
- Bosch, F
- Abrisqueta, P
- Stamatopoulos, K
- Espinet, B
Grupos
Abstract
Patients with chronic lymphocytic leukemia (CLL) harboring TP53 aberrations (TP53abs; chromosome 17p deletion and/or TP53 mutation) exhibit an unfavorable clinical outcome. Chromosome 8 abnormalities, namely losses of 8p (8p-) and gains of 8q (8q+) have been suggested to aggravate the outcome of patients with TP53abs. However, the reported series were small, thus hindering definitive conclusions. To gain insight into this issue, we assessed a series of 101 CLL patients harboring TP53 disruption. The frequency of 8p- and 8q+ was 14.7% and 17.8% respectively. Both were associated with a significantly (P < 0.05) higher incidence of a complex karyotype (CK, >= 3 abnormalities) detected by chromosome banding analysis (CBA) compared to cases with normal 8p (N-8p) and 8q (N-8q), respectively. In univariate analysis for 10- year overall survival (OS), 8p- (P = 0.002), 8q+ (P = 0.012) and CK (P = 0.009) were associated with shorter OS. However, in multivariate analysis only CK (HR = 2.47, P = 0.027) maintained independent significance, being associated with a dismal outcome regardless of chromosome 8 abnormalities. In conclusion, our results highlight the association of chromosome 8 abnormalities with CK amongst CLL patients with TP53abs, while also revealing that CK can further aggravate the prognosis of this aggressive subgroup.
Datos de la publicación
- ISSN/ISSNe:
- 1949-2553, 1949-2553
- Tipo:
- Article
- Páginas:
- 80916-80924
- PubMed:
- 27821812
- Factor de Impacto:
- 1,994 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
Oncotarget IMPACT JOURNALS LLC
Citas Recibidas en Web of Science: 25
Documentos
- No hay documentos
Filiaciones
Keywords
- CLL; TP53 aberrations; chromosome 8 abnormalities; complex karyotype; prognosis
Campos de Estudio
Cita
Blanco G,Puiggros A,Baliakas P,Athanasiadou A,Garcia M,Collado R,Xochelli A,Rodriguez M,Ortega M,Calasanz MJ,Luno E,Vargas M,Grau J,Martinez C,Valiente A,CERVERA J,Anagnostopoulos A,Gimeno E,Abella E,Stalika E,Hernandez JM,Ortuno FJ,Robles D,Ferrer A,Ivars D,Gonzalez M,Bosch F,Abrisqueta P,Stamatopoulos K,Espinet B. Karyotypic complexity rather than chromosome 8 abnormalities aggravates the outcome of chronic lymphocytic leukemia patients with TP53 aberrations. Oncotarget. 2016. 7. (49):p. 80916-80924. IF:5,168. (1).