Continuous Positive Airway Pressure Improves Quality of Life in Women with Obstructive Sleep Apnea A Randomized Controlled Trial

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Campos-Rodriguez, F
  • Queipo-Corona, C
  • Carmona-Bernal, C
  • Jurado-Gamez, B
  • Cordero-Guevara, J
  • Reyes-Nunez, N
  • Troncoso-Acevedo, F
  • Abad-Fernandez, A
  • Teran-Santos, J
  • Caballero-Rodriguez, J
  • Martin-Romero, M
  • Encabo-Motino, A
  • Sacristan-Bou, L
  • Navarro-Esteva, J
  • Somoza-Gonzalez, M
  • Masa, JF
  • Sanchez-Quiroga, MA
  • Jara-Chinarro, B
  • Orosa-Bertol, B
  • Spanish Sleep Network

Grupos

Abstract

Rationale: Continuous positive airway pressure (CPAP) is the treatment of choice in patients with symptomatic obstructive sleep apnea (OSA). CPAP treatment improves quality of life (QoL) in men with OSA, but its role in women has not yet been assessed. Objectives: To investigate the effect of CPAP on QoL in women with moderate to severe OSA. Methods: We conducted a multicenter, open-label randomized controlled trial in 307 consecutive women diagnosed with moderate to severe OSA (apnea-hypopnea index, >= 15) in 19 Spanish sleep units. Women were randomized to receive effective CPAP therapy (n = 151) or conservative treatment (n = 156) for 3 months. The primary endpoint was the change in QoL based on the Quebec Sleep Questionnaire. Secondary endpoints included changes in daytime sleepiness, mood state, anxiety, and depression. Data were analyzed on an intention-to-treat basis with adjustment for baseline values and other relevant clinical variables. Measurements and Main Results: The women in the study had a mean (SD) age of 57.1 (10.1) years and a mean (SD) Epworth Sleepiness Scale score of 9.8 (4.4), and 77.5% were postmenopausal. Compared with the control group, the CPAP group achieved a significantly greater improvement in all QoL domains of the Quebec Sleep Questionnaire (adjusted treatment effect between 0.53 and 1.33; P < 0.001 for all domains), daytime sleepiness (-2.92; P < 0.001), mood state (-4.24; P = 0.012), anxiety (-0.89; P = 0.014), depression ( 0.85; P = 0.016), and the physical component summary of the 12-item Short Form Health Survey (2.78; P = 0.003). Conclusions: In women with moderate or severe OSA, 3 months of CPAP therapy improved QoL, mood state, anxiety and depressive symptoms, and daytime sleepiness compared with conservative treatment.

Datos de la publicación

ISSN/ISSNe:
1073-449X, 1535-4970

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE  AMER THORACIC SOC

Tipo:
Article
Páginas:
1286-1294
PubMed:
27181196
Factor de Impacto:
6,137 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 54

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Keywords

  • obstructive sleep apnea; women; continuous positive airway pressure; quality of life; Quebec Sleep Questionnaire

Campos de Estudio

Proyectos y Estudios Clínicos

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Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

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Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI12/01363 . INSTITUTO DE SALUD CARLOS III . 2013

EFECTO DEL TRATAMIENTO CON CPAP SOBRE LAS CIFRAS TENSIONALES EN PACIENTES CON HIPERTENSION ARTERIAL REFRACTARIA. ESTUDIO MULTICENTRICO Y ALEATORIZADO. ESTUDIO HIPARCO

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI09/01647 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

INTENSIFICACION DR. MIGUEL ANGEL MARTINEZ GARCIA

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

INT14/00003 . INSTITUTO DE SALUD CARLOS III . 2015

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