Portal de investigación
Extensive migration of young neurons into the infant human frontal lobe
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Paredes, MF
- James, D
- Kim, H
- Cotter, JA
- Ng, C
- Sandoval, K
- Rowitch, DH
- Xu, D
- McQuillen, PS
- Garcia-Verdugo, JM
- Huang, EJ
- Alvarez-Buylla, A
Grupos
Abstract
The first few months after birth, when a child begins to interact with the environment, are critical to human brain development. The human frontal lobe is important for social behavior and executive function; it has increased in size and complexity relative to other species, but the processes that have contributed to this expansion are unknown. Our studies of postmortem infant human brains revealed a collection of neurons that migrate and integrate widely into the frontal lobe during infancy. Chains of young neurons move tangentially close to the walls of the lateral ventricles and along blood vessels. These cells then individually disperse long distances to reach cortical tissue, where they differentiate and contribute to inhibitory circuits. Late-arriving interneurons could contribute to developmental plasticity, and the disruption of their postnatal migration or differentiation may underlie neurodevelopmental disorders.
Datos de la publicación
- ISSN/ISSNe:
- 0036-8075, 1095-9203
- Tipo:
- Article
- Páginas:
- -
- PubMed:
- 27846470
- Factor de Impacto:
- 13,745 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
SCIENCE AMER ASSOC ADVANCEMENT SCIENCE
Citas Recibidas en Web of Science: 205
Documentos
- No hay documentos
Filiaciones
Proyectos y Estudios Clínicos
TERAPIA CELULAR DESPUES DEL ICTUS DIRIGIDA MEDIANTE CAMPOS MAGNETICOS. APLICACION DE RM-TDI Y TRACTOGRAFIA CEREBRAL EN ICTUS PARA LA VALORACION DEL DAÑO NEUROLOGICO
Investigador Principal: JOSÉ MANUEL GARCÍA VERDUGO
2015_0534_GARCIA_VERDUGO_MAPFRE . 2015
Cita
Paredes MF,James D,GIL S,Kim H,Cotter JA,Ng C,Sandoval K,Rowitch DH,Xu D,McQuillen PS,Garcia JM,Huang EJ,Alvarez A. Extensive migration of young neurons into the infant human frontal lobe. Science. 2016. 354. (6308):aaf7073. IF:37,205. (1).