Decreasing prevalence of HCV coinfection in all risk groups for HIV infection between 2004 and 2011 in Spain

Fecha de publicación: 01/05/2015

Autores de IIS La Fe

Marta Montero Alonso

Autor

Participantes ajenos a IIS La Fe

Serrano-Villar, S
Sobrino-Vegas, P
Monge, S
Dronda, F
Hernando, A
Viciana, P
Clotet, B
Pineda, JA
del Amo, J
Moreno, S
CoRIS

Grupos

Investigacion clínica en enfermedades crónicas e Infección por el VIH

Investigador establecido

Marta Montero Alonso

Abstract

While hepatitis C virus (HCV) infection seems to be expanding among HIV-infected men who have sex with men (MSM), the rate of coinfection in intravenous drug users (IDU) is assumed to remain constant. We evaluated the serial prevalence of HIV/HCV coinfection across all risk groups for HIV infection in Spain. We used data from 7045 subjects included in the multicentre, prospective Spanish Cohort of Adult HIV-infected Patients (CoRIS) between 2004 and 2011. We analysed risk factors for HIV/HCV coinfection by logistic regression analyses. The prevalence of HIV/HCV coinfection decreased from 25.3% (95% CI, 23.1-27.5) in 2004-2005 to 8.2% (95% CI, 6.9-9.5) in 2010-2011. This trend was consistently observed from 2004 to 2011 among all risk groups: IDU, 92.4% to 81.4%; MSM, 4.7% to 2.6%; heterosexual men, 13.0-8.9%; and heterosexual women, 14.5-4.0% (all P<0.05). Strongest risk factors for HIV/HCV coinfection were IDU (OR, 54.9; 95% CI, 39.4-76.4), birth decade 1961-1970 (OR, 2.1; 95% CI, 1.1-3.7) and low educational level (OR, 2.4; 95% CI, 1.6-3.5). Hence, the prevalence of HIV/HCV coinfection decreased in Spain between 2004 and 2011. This decline was observed across all risk groups and is likely to be explained by a declining burden of HCV in the general population.

Datos de la publicación

ISSN/ISSNe:: 1352-0504, 1365-2893
Tipo:: Article
Páginas:: 496-503
DOI:: 10.1111/jvh.12353
PubMed:: 25363502
Factor de Impacto:: 1,863 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Métricas

Filiaciones

Serrano-Villar, S:: Univ Hosp Ramon & Cajal, Dept Infect Dis, Madrid 28034, Spain

IRYCIS, Madrid, Spain
Sobrino-Vegas, P:: Inst Salud Carlos III, Natl Ctr Epidemiol, Madrid, Spain
Monge, S:: Inst Salud Carlos III, Natl Ctr Epidemiol, Madrid, Spain
Dronda, F:: Univ Hosp Ramon & Cajal, Dept Infect Dis, Madrid 28034, Spain

IRYCIS, Madrid, Spain
Hernando, A:: Hosp Univ Doce Octubre, HIV Unit, Madrid, Spain

Univ Europea, Madrid, Spain
Montero, M:: Hosp La Fe, Infect Dis Unit, E-46009 Valencia, Spain
Viciana, P:: Hosp Virgen del Rocio, Clin Infect Dis Unit, Seville, Spain
Clotet, B:: Hosp Badalona Germans Trias & Pujol, HIV Unit, Barcelona, Spain
Pineda, JA:: Hosp Univ Valme, Infect Dis Unit, Seville, Spain
del Amo, J:: Inst Salud Carlos III, Natl Ctr Epidemiol, Madrid, Spain
Moreno, S:: Univ Hosp Ramon & Cajal, Dept Infect Dis, Madrid 28034, Spain

IRYCIS, Madrid, Spain