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Association Between Individual and Combined SNPs in Genes Related to Innate Immunity and Incidence of CMV Infection in Seropositive Kidney Transplant Recipients

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Fernandez-Ruiz, M
  • Corrales, I
  • Arias, M
  • Campistol, JM
  • Gimenez, E
  • Crespo, J
  • Lopez-Oliva, MO
  • Martin-Moreno, PL
  • Llamas-Fuente, F
  • Gutierrez, A
  • Garcia-Alvarez, T
  • Guerra-Rodriguez, R
  • Calvo, N
  • Fernandez-Rodriguez, A
  • Tabernero-Romo, JM
  • Navarro, MD
  • Ramos-Verde, A
  • Aguado, JM
  • Navarro, D
  • OPERA Study Grp

Abstract

In this study, we assessed the association between single-nucleotide polymorphisms (SNPs) in seven candidate genes involved in orchestrating the immune response against cytomegalovirus (CMV) and the 12-month incidence of CMV infection in 315 CMV-seropositive kidney transplant (KT) recipients. Patients were managed either by antiviral prophylaxis or preemptive therapy. CMV infection occurred in 140 patients (44.4%), including 13 episodes of disease. After adjusting for various clinical covariates, patients harboring T-allele genotypes of interleukin-28B (IL28B) (rs12979860) SNP had lower incidence of CMV infection (adjusted hazard ratio [aHR]: 0.66; 95% confidence interval [CI]: 0.46-0.96; p-value = 0.029). In the analysis restricted to patients not receiving prophylaxis, carriers of the TT genotype of toll-like receptor 9 (TLR9) (rs5743836) SNP had lower incidence of infection (aHR: 0.61; 95% CI: 0.38-0.96; p-value = 0.035), whereas the GG genotype of dendritic cell-specific ICAM 3-grabbing nonintegrin (DC-SIGN) (rs735240) SNP exerted the opposite effect (aHR: 1.86; 95% CI: 1.18-2.94; p-value = 0.008). An independent association was found between the number of unfavorable SNP genotypes carried by the patient and the incidence of CMV infection. In conclusion, specific SNPs in IL28B, TLR9 and DC-SIGN genes may play a role in modulating the susceptibility to CMV infection in CMV-seropositive KT recipients.

Datos de la publicación

ISSN/ISSNe:
1600-6135, 1600-6143

AMERICAN JOURNAL OF TRANSPLANTATION  ELSEVIER SCIENCE INC

Tipo:
Article
Páginas:
1323-1335
PubMed:
25777542
Factor de Impacto:
2,819 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 41

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