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Obstructive sleep apnea is associated with cancer mortality in younger patients

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Campos-Rodriguez, F
  • Duran-Cantolla, J
  • de la Pena, M
  • Masdeu, MJ
  • Gonzalez, M
  • del Campo, F
  • Serra, PC
  • Marin, JM
  • Barbe, F
  • Martinez, M
  • Farre, R
  • Montserrat, JM
  • Spanish Sleep Network

Grupos

Abstract

Objective: The association between obstructive sleep apnea (OSA) and cancer mortality has scarcely been studied. The objective of this study was to investigate whether OSA is associated with increased cancer mortality in a large cohort of patients with OSA suspicion. Methods: This was a multicenter study in consecutive patients investigated for suspected OSA. OSA severity was measured by the apnea-hypoppea index (AHI) and the hypoxemia index (% night-time spent with oxygen saturation <90%, TSat(90)). The association between OSA severity and cancer mortality was assessed using Cox's proportional regression analyses after adjusting for relevant confounders. Results: In all, 5427 patients with median follow-up of 4.5 years were included. Of these, 527(9.7%) were diagnosed with cancer. Log-transformed TSat(90) was independently associated with increased cancer mortality in the entire cohort (hazard ratio [HR], 1.21; 95% confidence interval [CI], 1.03-1.42), as well as in the group of patients with cancer (HR, 1.19; 95% CI, 1.02-1.41). The closest association was shown in patients <65 years in both the AHI (continuous log-transformed AHI: HR, 1.87; 95% CI, 1.1-3.2; upper vs lower AHI tertile: HR, 3.98; 95% CI, 1.14-3.64) and the TSat(90) (continuous log-transformed TSat(90): HR, 1.73; 95% CI, 1.23-2.4; upper vs lower TSat(90) tertile: HR, 14.4; 95% CI, 1.85-111.6). Conclusions: OSA severity was associated with increased cancer mortality, particularly in patients aged <65 years. (C) 2014 Elsevier B.V. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
1389-9457, 1878-5506

SLEEP MEDICINE  ELSEVIER SCIENCE BV

Tipo:
Article
Páginas:
742-748
PubMed:
24907033
Factor de Impacto:
1,406 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 93

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Keywords

  • Sleep apnea; Sleep-dfsordered breathing; Cancer; Mortality; Intermittent hypoxemia; Obstructive sleep apnea

Campos de Estudio

Proyectos y Estudios Clínicos

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Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

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ASOCIACION ENTRE TRASTORNOS RESPIRATORIOS DEL SUEÑO Y TASA DE CRECIMIENTO DEL MELANOMA CUTANEO

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI12/01363 . INSTITUTO DE SALUD CARLOS III . 2013

EFECTO DEL TRATAMIENTO CON CPAP SOBRE LAS CIFRAS TENSIONALES EN PACIENTES CON HIPERTENSION ARTERIAL REFRACTARIA. ESTUDIO MULTICENTRICO Y ALEATORIZADO. ESTUDIO HIPARCO

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI09/01647 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

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