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Rationale and Methodology of the SARAH Trial: Long-Term Cardiovascular Outcomes in Patients With Resistant Hypertension and Obstructive Sleep Apnea

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Sapina-Beltran, E
  • Torres, G
  • Martinez-Alonso, M
  • Sanchez-de-la-Torre, M
  • Franch, M
  • Bravo, C
  • Masa, JF
  • Felez, M
  • Fortuna-Gutierrez, AM
  • Abad, J
  • Garcia-Rio, F
  • Drager, LF
  • Chi-Hang, RL
  • Barbe, F
  • Dalmases, M

Grupos

Abstract

Introduction: Patients with resistant hypertension (RH) have a high risk of developing cardiovascular events; therefore, new therapeutic approaches to better control blood pressure may be useful in improving cardiovascular outcomes. The prevalence of obstructive sleep apnea (OSA) is very high among patients with RH. Continuous positive airway pressure (CPAP) has been shown to be an effective treatment for reducing blood pressure in patients with RH. Nevertheless, the long-term effect of CPAP treatment on cardiovascular outcomes has not been explored. The main objective of the SARAH study is to assess the impact of OSA and its treatment on cardiovascular outcomes (morbidity and mortality) in patients with RH. Methods: This study is a multi-center, prospective, observational cohort study. A total of 1371 patients with RH will be enrolled in the study and followed once a year for five years. At inclusion, ambulatory blood pressure monitoring (ABPM) and a sleep study will be performed in all subjects. Socio-demographic, clinical and cardiovascular variables will be collected at baseline and follow-up. Subsequently, subjects with OSA will be managed according to local standard practice. Based on the OSA diagnosis and its treatment, three cohorts of subjects with RH will be defined: non-OSA, treated OSA and non-treated OSA. Conclusions: This study will contribute to elucidating the long-term impact of OSA treatments on blood pressure control and cardiovascular outcomes in patients with RH. These results will contribute to improve the cardiovascular prognosis of patients with RH. (C) 2018 SEPAR. Published by Elsevier Espana, S.L.U. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0300-2896, 1579-2129

ARCHIVOS DE BRONCONEUMOLOGIA  ELSEVIER DOYMA SL

Tipo:
Article
Páginas:
518-523
PubMed:
29801678
Factor de Impacto:
0,396 SCImago ℠
Cuartil:
Q3 SCImago ℠

Citas Recibidas en Web of Science: 11

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Keywords

  • Ambulatory blood pressure monitoring; Continuous positive airway pressure; Resistant hypertension; Sleep apnea

Campos de Estudio

Proyectos y Estudios Clínicos

INTENSIFICACION DR. MIGUEL MARTINEZ GARCIA

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

INT11/037 . 2012

ASOCIACION ENTRE TRASTORNOS RESPIRATORIOS DEL SUEÑO Y TASA DE CRECIMIENTO DEL MELANOMA CUTANEO

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI12/01363 . INSTITUTO DE SALUD CARLOS III . 2013

EFECTO DEL TRATAMIENTO CON CPAP SOBRE LAS CIFRAS TENSIONALES EN PACIENTES CON HIPERTENSION ARTERIAL REFRACTARIA. ESTUDIO MULTICENTRICO Y ALEATORIZADO. ESTUDIO HIPARCO

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI09/01647 . INSTITUTO DE SALUD CARLOS III; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010

INTENSIFICACION DR. MIGUEL ANGEL MARTINEZ GARCIA

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

INT14/00003 . INSTITUTO DE SALUD CARLOS III . 2015

ASOCIACIÓN ENTRE LOS TRASTORNOS RESPIRATORIOS DEL SUEÑO Y EL PRONÓSTICO DEL MELANOMA. ESTUDIO LONGITUDINAL Y MULTICÉNTRICO EN 443 PACIENTES CON MELANOMA CUTÁNEO MALIGNO.

Investigador Principal: MIGUEL ÁNGEL MARTÍNEZ GARCÍA

PI16/01772 . INSTITUTO DE SALUD CARLOS III . 2017

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