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  3. High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control

High Plasma Levels of sTNF-R1 and CCL11 Are Related to CD4+T-Cells Fall in Human Immunodeficiency Virus Elite Controllers With a Sustained Virologic Control

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Gutierrez-Rivas, M
  • Jimenez-Sousa, MA
  • Rallon, N
  • Jimenez, JL
  • Restrepo, C
  • Leon, A
  • Gonzalez-Garcia, J
  • Munoz-Fernandez, MA
  • Benito, JM
  • Resino, S
  • ECRIS Integrated Spanish AIDS Res

Grupos

Abstract

Our aim was to analyze the relationship between plasma inflammatory biomarkers and CD4+ T-cells evolution in human immunodeficiency virus (HIV) elite controllers (HIV-ECs) with a suppressed viremia. We carried out a retrospective study in 30 HIV-ECs classified into two groups: those showing no significant loss of CD4+ T-cells during the observation period (stable CD4+, n = 19) and those showing a significant decrease of CD4+ T-cells (decline CD4+, n = 11). Baseline plasma biomarkers were measured using a multiplex immunoassay: sTNF-R1, TRAIL, sFas (APO), sFasL, TNF-alpha, IL-beta, IL-18, IL-6, IL-10, IP-10, MCP-1, MIP-1 alpha, MIP-1 beta, RANTES, SDF1 alpha, GRO-alpha, and CCL11. Baseline levels of sTNF-R1 and CCL11 and sTNF-R1 TTNF-alpha ratio correlated with the slope of CD4+ T-cells (cells/mu l/year) during follow-up [r = -0.370 (p = 0.043), r = -0.314 (p = 0.091), and r = -0.381 (p = 0.038); respectively]. HIV-ECs with declining CD4+ T-cells had higher baseline plasma levels of sTNF-R1 [1,500.7 (555.7; 2,060.7) pg/ml vs. 450.8 (227.9; 1,263.9) pg/ml; p = 0.018] and CCL11 [29.8 (23.5; 54.9) vs. 19.2 (17.8; 29.9) pg/ml; p = 0.041], and sTNF-R1/TNF-alpha ratio [84.7 (33.2; 124.2) vs. 25.9 (16.3; 75.1); p = 0.012] than HIV-1 ECs with stable CD4+ T-cells. The area under the receiver operating characteristic (ROC) curve [area under ROC curve (AUROC)] were 0.758 +/- 0.093 (sTNF-R1), 0.727 +/- 0.096 (CCL11), and 0.777 +/- 0.087 (sTNF-R1/TNF-alpha). The cut-off of 75th percentile (high values) for these biomarkers had 71.4% positive predictive value and 73.9% negative predictive value for anticipating the evolution of CD4+ T-cells. In conclusion, the loss of CD4+ T-cells in HIV-ECs was associated with higher levels of two plasma inflammatory biomarkers (sTNF-R1 and CCL11), which were also reasonably accurate for the prediction of the CD4+ T-cells loss.

Datos de la publicación

ISSN/ISSNe:
1664-3224, 1664-3224

Frontiers in immunology  FRONTIERS MEDIA SA

Tipo:
Article
Páginas:
1399-1399
PubMed:
29967620
Factor de Impacto:
2,021 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 2

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Keywords

  • human immunodeficiency virus; elite controllers; inflammation; plasma biomarkers; acquired immune deficiency syndrome; progression

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