A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Sanchez-Munoz, A
- Guma, J
- Domenech, M
- Meana, JA
- Garcia-Sanchez, J
- Bastus, R
- Girones, R
- Gonzalez-Billalabeitia, E
- Sagastibelza, N
- Ochenduszko, S
- Sanchez, A
- Terrasa, J
- Germa-Lluch, JR
- García Del Muro X
- on behalf of the Spanish Germ Cell Cancer Group
Grupos
Abstract
Objective: The aim of this study was to assess a risk-adapted strategy for stage I seminoma guided by the presence of rete testis invasion. Methods: Between January 2013 and December 2015, a total of 135 consecutive patients with stage I seminoma from 18 Spanish tertiary hospitals were included in a prospective multicenter study. Median patient age was 38 years (range 22-60). Preoperative beta-human chorionic gonadotropin was elevated in 9.6% of patients. Rete testis invasion was present in 47.4% of patients. After orchiectomy, subjects with rete testis invasion were treated with 2 courses of adjuvant carboplatin (area under the curve of 7, with 21day interval). Those without this risk factor were managed by surveillance. Disease-free survival (DFS) and overall survival (OS) were estimated with the Kaplan-Meier method. Results: After a median follow-up time of 33 months, only 6 relapses were recorded (5 on surveillance, 1 after carboplatin). These cases were rescued with BEP or EP chemotherapy, and all 135 patients are currently disease free without sequelae. Threeyear DFS was 92.0 and 98.2% for patients on surveillance and after carboplatin, respectively. Three-year OS was 100%. Conclusion: A risk-adapted approach based on rete testis invasion as a single risk factor is feasible and yielded an excellent outcome with a 3-year DFS of 94.9%. (C) 2018 S. Karger AG, Basel
Datos de la publicación
- ISSN/ISSNe:
- 0030-2414, 1423-0232
- Tipo:
- Article
- Páginas:
- 8-12
- DOI:
- 10.1159/000487438
- PubMed:
- 29587278
- Factor de Impacto:
- 0,846 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
ONCOLOGY KARGER
Citas Recibidas en Web of Science: 11
Documentos
- No hay documentos
Filiaciones
Keywords
- Adjuvant chemotherapy; Carboplatin; Rete testis invasion; Seminoma; Surveillance
Campos de Estudio
Cita
APARICIO J,Sanchez A,Guma J,Domenech M,Meana JA,Garcia J,Bastus R,Girones R,Gonzalez E,Sagastibelza N,Ochenduszko S,Sanchez A,Terrasa J,Germa JR,García Del Muro X,O. A Risk-Adapted Approach to Patients with Stage I Seminoma according to the Status of Rete Testis: The Fourth Spanish Germ Cell Cancer Group Study. Oncology. 2018. 95. (1):p. 8-12. IF:2,278. (3).
Portal de investigación