Portal de investigación
Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Villalba, A
- Santiago, M
- Freiria, C
Grupos
Abstract
Background: Anti-D alloimmunization can occur when platelets from RhD-positive donors are transfused to RhD-negative patients, due to red blood cell residues in the platelet concentrates. Methods: Our objective was to analyze the anti-D alloimmunization rate in a selected group of women under 55 years of age diagnosed with acute leukemia over an 18-year period. We focused the analysis on RhD-negative patients who received RhD-positive platelet transfusions. Results: From January 1998 to October 2016, 382 women under 55 years were diagnosed with acute leukemia. A total of 56 patients were RhD-negative, and 48 (85.7%) received RhD-positive platelets. The median number of platelet concentrates transfused per patient was 23, and 48% of all platelet transfusions were RhD-positive. The 48 RhD-negative patients received a total of 949 RhD-positive platelet concentrates. Two patients developed anti-D: a 36-year-old woman with M3 acute myeloblastic leukemia and a 52-year-old patient with a secondary acute myeloblastic leukemia. Conclusion: We conclude that there is a need for agreement in the transfusion guidelines on the recommendation of anti-D alloimmunization prophylaxis. We suggest a possible benefit in favor of anti-D prophylaxis in childbearing women with acute leukemia. (c) 2018 S. Karger GmbH, Freiburg
Datos de la publicación
- ISSN/ISSNe:
- 1660-3796, 1660-3818
- Tipo:
- Article
- Páginas:
- 162-166
- DOI:
- 10.1159/000488804
- PubMed:
- 29928170
- Factor de Impacto:
- 0,737 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
TRANSFUSION MEDICINE AND HEMOTHERAPY KARGER
Citas Recibidas en Web of Science: 3
Documentos
- No hay documentos
Filiaciones
Keywords
- Platelet transfusion; Anti-D alloimmunization; Acute leukemia
Campos de Estudio
Cita
Villalba A,Santiago M,Freiria C,MONTESINOS P,GOMEZ I,FUENTES C,RODRIGUEZ R,FERNANDEZ JM,SANZ G,SANZ MA,CARPIO N,SOLVES P. Anti-D Alloimmunization after RhD-Positive Platelet Transfusion in RhD-Negative Women under 55 Years Diagnosed with Acute Leukemia: Results of a Retrospective Study. Transfus. Med. Hemother. 2018. 45. (3):p. 162-166. IF:3,000. (2).