1. Inicio
  2. Publicaciones
  3. Exosome levels in human body fluids: A tumor marker by themselves?

Exosome levels in human body fluids: A tumor marker by themselves?

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Cappello, F
  • Logozzi, M
  • Campanella, C
  • Bavisotto, CC
  • Properzi, F
  • Fais, S

Grupos

Abstract

Despite considerable research efforts, the finding of reliable tumor biomarkers remains challenging and unresolved. In recent years a novel diagnostic biomedical tool with high potential has been identified in extracellular nanovesicles or exosomes. They are released by the majority of the cells and contain detailed molecular information on the cell of origin including tumor hallmarks. Exosomes can be isolated from easy accessible body fluids, and most importantly, they can provide several biomarkers, with different levels of specificity. Recent clinical evidence shows that the levels of exosomes released into body fluids may themselves represent a predictive/diagnostic of tumors, discriminating cancer patients from healthy subjects. The aim of this review is to highlight these latest challenging findings to provide novel and ground breaking ideas for successful tumor early diagnosis and follow-up. (C) 2016 Elsevier B.V. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0928-0987, 1879-0720

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES  ELSEVIER

Tipo:
Article
Páginas:
93-98
PubMed:
27640113
Factor de Impacto:
1,016 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 150

Documentos

  • No hay documentos

Métricas

Filiaciones mostrar / ocultar

Keywords

  • Extracellular vesicles; Exosomes; Biomarkers; Body fluids; Early diagnosis; Follow-up; Prostate cancer

Campos de Estudio

Cita

Compartir