Tobacco smoking and its association with cognition in first episode psychosis patients Lauren

Fecha de publicación: 01/02/2018

Autores de IIS La Fe

Vicent Balanza Martinez

Autor

Participantes ajenos a IIS La Fe

Hickling, LM
Perez-Iglesias, R
Ortiz-García de la Foz V
McGuire, P
Crespo-Facorro, B
Ayesa-Arriola, R

Abstract

Available evidence suggests that nicotine may enhance cognitive functioning. Moreover, it has been suggested that the high prevalence of smoking in people with schizophrenia is in part due to self-medication behaviour to alleviate cognitive deficits. We assessed the association between tobacco smoking and cognitive functioning in a large population of first episode psychosis (FEP) patients (n = 304) and healthy controls (n = 156). Smokers were not tobacco deprived, or were minimally deprived (<= 2 h). Verbal memory, visual memory, working memory, processing speed, executive function, motor dexterity and attention were assessed. The smoking prevalence among the PEP group was 57% (n = 174). The age at which patients began smoking cigarettes regularly was 16.2 years (SD = 3.1), an average of 12 years before experiencing the first frank symptoms of psychosis (age of onset = 28.8; SD = 93). The number of cigarettes smoked per day was 19.6 (SD = 9.4), significantly more than healthy controls [11.0 (SD = 7.6); p < 0.001]. ANCOVA analysis did not show any significant difference between smokers and non-smokers in in the performance of any of the cognitive tasks in the PEP group or in the healthy control group, independent of gender, age, education or premorbid IQ. This suggests chronic exposure to nicotine through cigarette smoking is not associated with cognitive functioning in first-episode psychosis. These findings do not support the nicotine self-medication hypothesis as a contributor to the high prevalence of smoking among individuals suffering from serious mental illness. (C) 2017 Elsevier B.V. All rights reserved.

Datos de la publicación

ISSN/ISSNe:: 0920-9964, 1573-2509
Tipo:: Article
Páginas:: 269-273
DOI:: 10.1016/j.schres.2017.04.018
PubMed:: 28412088
Factor de Impacto:: 2,168 SCImago ℠
Cuartil:: Q1 SCImago ℠

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Filiaciones

Hickling, LM:: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK

Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk, London SE5 8AF, England
Perez-Iglesias, R:: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK

CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain

Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk, London SE5 8AF, England

Ctr Invest Biomed Red Salud Mental, CIBERSAM, Santander, Spain
Ortiz-García de la Foz V:: Marqués de Valdecilla University Hospital, IDIVAL, Santander, Spain

Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain

CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain
Balanza-Martinez, V:: Section of Psychiatry and Psychological Medicine, Department of Medicine, University of Valencia Medical School, Valencia, Spain

Instituto de Investigación. Service of Psychiatry, La Fe University and Polytechnic Hospital, IIISLaFe, ISNPR, Valencia, Spain

Centro de Investigación Biomédica en Red en Salud Mental (CIBERSAM), Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation, Madrid, Spain

Univ Valencia, Dept Med, Sect Psychiat & Psychol Med, Med Sch, Valencia, Spain

Instituto de Investigación. La Fe Univ & Polytech Hosp, Serv Psychiat, IllSLaFe, ISNPR, Valencia, Spain

Inst Salud Carlos III, Spanish Minist Sci & Innovat, Ctr Invest Biomed Red Salud Mental CIBERSAM, Madrid, Spain
McGuire, P:: Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, De Crespigny Park, London SE5 8AF, UK

Kings Coll London, Inst Psychiat Psychol & Neurosci, Dept Psychosis Studies, De Crespigny Pk, London SE5 8AF, England
Crespo-Facorro, B:: Marqués de Valdecilla University Hospital, IDIVAL, Santander, Spain

Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain

CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain

Marques Valdecilla Univ Hosp, IDIVAL, Santander, Spain

Univ Cantabria, Sch Med, Dept Psychiat, Santander, Spain

Ctr Invest Biomed Red Salud Mental, CIBERSAM, Santander, Spain
Ayesa-Arriola, R:: Marqués de Valdecilla University Hospital, IDIVAL, Santander, Spain

Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain

CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Santander, Spain

Marques Valdecilla Univ Hosp, IDIVAL, Santander, Spain

Univ Cantabria, Sch Med, Dept Psychiat, Santander, Spain

Ctr Invest Biomed Red Salud Mental, CIBERSAM, Santander, Spain

Keywords

Cognition; Tobacco; First-episode psychosis; Smoking; Psychosis

Proyectos y Estudios Clínicos

INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.

Investigador Principal: VICENT BALANZA MARTINEZ

PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017

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