International variations and trends in the treatment for retinopathy of prematurity

Data de publicació: 01/10/2017

Autors de IIS La Fe

Máximo Vento Torres

Autor

Autors aliens a IIS La Fe

Darlow, Brian A.
Lui, Kei
Kusuda, Satoshi
Reichman, Brian
Hakansson, Stellan
Bassler, Dirk
Modi, Neena
Lee, Shoo K.
Lehtonen, Liisa
Isayama, Tetsuya
Sjors, Gunnar
Helenius, Kjell K.
Adams, Mark
Rusconi, Franca
Morisaki, Naho
Shah, Prakesh S.
International Network Evaluating

Grups d'Investigació

Perinatología

Leader

Máximo Vento Torres

Abstract

Objective To compare the rates of retinopathy of prematurity (ROP) and treatment of ROP by laser or intravitreal anti-vascular endothelial growth factor among preterm neonates from high-income countries participating in the International Network for Evaluating Outcomes (iNeo) of neonates. Methods A retrospective cohort study was conducted on extremely preterm infants weighing <1500 g at 24(0) to 27(6) weeks' gestation who were admitted to neonatal units in Australia/New Zealand, Canada, Finland, Israel, Japan, Spain, Sweden, Switzerland, Tuscany (Italy) and the UK between 2007 and 2013. Pairwise comparisons of ROP treatment in survivors between countries were evaluated by Poisson and multivariable logistic regression analyses after adjustment for confounders. A composite outcome of death or ROP treatment was compared between countries using logistic regression and standardised ratios. Results Of 48 087 infants included in the analysis, 81.8% survived to 32 weeks postmenstrual age, and 95% of survivors were screened for ROP. Rates of any ROP ranged from 25.2% to 91.0% in Switzerland and Japan, respectively, among those examined. The overall rate of those receiving treatment was 24.9%, which varied from 4.3% to 30.4%. Adjusted risk ratios for ROP treatment were lower for Switzerland in all pairwise comparisons, whereas Japan displayed significantly higher ratios. Comparisons of the composite outcome between countries revealed similar, but less marked differences. Conclusions Rates of any ROP and ROP treatment varied significantly between iNeo members, while an overall decline in ROP treatment was observed during the study period. It is unclear whether these variations represent differences in care practices, diagnosis and/or treatment thresholds.

Dades de la publicació

ISSN/ISSNe:: 0007-1161, 1468-2079
Tipus:: Article
Pàgines:: 1399-1404
DOI:: 10.1136/bjophthalmol-2016-310041
PubMed:: 28270489
Factor d'Impacte:: 2,173 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Darlow, Brian A.:: Univ Otago, Dept Paediat, Australia & New Zealand Neonatal Network, Christchurch, New Zealand
Lui, Kei:: Univ New South Wales, Australian & New Zealand Neonatal Network, Royal Hosp Women, Natl Perinatal Epidemiol & Stat Unit, Randwick, NSW, Australia
Kusuda, Satoshi:: Tokyo Womens Med Univ, Maternal & Perinatal Ctr, Neonatal Res Network Japan, Shinjuku Ku, Tokyo, Japan
Reichman, Brian:: Sheba Med Ctr, Israel Neonatal Network, Gertner Inst Epidemiol & Hlth Policy Res, Tel Hashomer, Israel
Hakansson, Stellan:: Umea Univ Hosp, Dept Pediat, Swedish Neonatal Qual Register, Neonatal Serv, Umea, Sweden
Bassler, Dirk:: Univ Zurich, Univ Hosp Zurich, Dept Neonatol, Swiss Neonatal Network, Frauenklinikstr, Zurich, Switzerland
Modi, Neena:: Imperial Coll London, UK Neonatal Collaborat, Sect Neonatal Med, Dept Med,Neonatal Data Anal Unit, Chelsea & Westminster Hosp Campus, London, England
Lee, Shoo K.:: Mt Sinai Hosp, Dept Paediat, Toronto, ON, Canada

Univ Toronto, Toronto, ON, Canada

Mt Sinai Hosp, Maternal Infant Care Res Ctr, Canadian Neonatal Network, Toronto, ON, Canada
Lehtonen, Liisa:: Turku Univ Hosp, Dept Pediat, Finnish Med Birth Register, Turku, Finland

Turku Univ Hosp, Dept Pediat, Register Congenital Malformat, Turku, Finland
Vento, Maximo:: Instituto de Investigación. Hlth Res Inst La Fe, Spanish Neonatal Network, Ave Fernando Abril Martorell, Valencia, Spain
Isayama, Tetsuya:: Mt Sinai Hosp, Dept Paediat, Toronto, ON, Canada

Univ Toronto, Toronto, ON, Canada
Sjors, Gunnar:: Uppsala Univ, Dept Womens & Childrens Hlth, Swedish Neonatal Qual Register, Uppsala, Sweden
Helenius, Kjell K.:: Turku Univ Hosp, Dept Pediat, Finnish Med Birth Register, Turku, Finland

Turku Univ Hosp, Dept Pediat, Register Congenital Malformat, Turku, Finland
Adams, Mark:: Univ Zurich, Univ Hosp Zurich, Dept Neonatol, Swiss Neonatal Network, Frauenklinikstr, Zurich, Switzerland
Rusconi, Franca:: Meyer Childrens Univ Hosp, Unit Epidemiol, TIN Toscane Online, Viale Pieraccini, Florence, Italy

Reg Hlth Agcy, Via Pietro Dazzi, Florence, Italy
Morisaki, Naho:: Natl Ctr Child Hlth & Dev, Neonatal Res Network Japan, Dept Social Med, Setagaya Ku, Tokyo, Japan
Shah, Prakesh S.:: Mt Sinai Hosp, Dept Paediat, Toronto, ON, Canada

Univ Toronto, Toronto, ON, Canada

Mt Sinai Hosp, Maternal Infant Care Res Ctr, Canadian Neonatal Network, Toronto, ON, Canada