Plasma metabolite score correlates with Hypoxia time in a newly born piglet model for asphyxia

Data de publicació: 01/08/2017

Autors de IIS La Fe

Julia Kuligowski

Autor
Ángel Sánchez Illana

Autor
Anna Parra Llorca

Autor
Guillermo Quintas Soriano

Autor
Máximo Vento Torres

Autor

Autors aliens a IIS La Fe

Solberg, R
Pankratov, L
Saugstad, OD

Grups d'Investigació

Perinatología

Leader

Máximo Vento Torres

Abstract

Hypoxic-ischemic encephalopathy (HIE) secondary to perinatal asphyxia is a leading cause of mortality and acquired long-term neurologic co-morbidities in the neonate. The most successful intervention for the treatment of moderate to severe HIE is moderate whole body hypothermia initiated within 6 h from birth. The objective and prompt identification of infants who are at risk of developing moderate to severe HIE in the critical first hours still remains a challenge. This work proposes a metabolite score calculated based on the relative intensities of three metabolites (choline, 6,8-dihydroxypurine and hypoxanthine) that showed maximum correlation with hypoxia time in a consolidated piglet model for neonatal hypoxia-ischemia. The metabolite score's performance as a biomarker for perinatal hypoxia and its usefulness for clinical grading and decision making have been assessed and compared to the performance of lactate which is currently considered the gold standard. For plasma samples withdrawn before and directly after a hypoxic insult, the metabolite score performed similar to lactate. However, it provided an enhanced predictive capacity at 2 h after resuscitation. The present study evidences the usefulness of the metabolite score for improving the early assessment of the severity of the hypoxic insult based on serial determinations in a minimally invasive biofluid. The applicability of the metabolite score for clinical diagnosis and patient stratification for hypothermia treatment has to be confirmed in multicenter trials involving newborns suffering from HIE.

Dades de la publicació

ISSN/ISSNe:: 2213-2317, 2213-2317
Tipus:: Article
Pàgines:: 1-7
DOI:: 10.1016/j.redox.2017.02.002
PubMed:: 28209514
Factor d'Impacte:: 2,203 SCImago ℠
Quartil:: Q1 SCImago ℠

Documents

No hi ha documents

Mètriques

Filiacions

Kuligowskia, J:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, Spain

Hlth Res Inst Hosp La Fe, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia, Spain
Solberg, R:: Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Oslo University Hospital - Rikshospitalet, Oslo, Norway

Department of Pediatrics, Vestfold Hospital Trust, Tønsberg, Norway

Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Pediat Res,Inst Surg Res, Oslo, Norway

Vestfold Hosp Trust, Dept Pediat, Tonsberg, Norway
Sanchez-Illana, A:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, Spain

Hlth Res Inst Hosp La Fe, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia, Spain
Pankratov, L:: Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Oslo University Hospital - Rikshospitalet, Oslo, Norway

Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Pediat Res,Inst Surg Res, Oslo, Norway
Parra-Llorca, A:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, Spain

Hlth Res Inst Hosp La Fe, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia, Spain
Quintas, G:: Human & Environmental Health & Safety (HEHS), Leitat Technological Center, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Instituto de Investigación. Unidad Analítica, Health Research Institute La Fe, Avenida Fernando Abril Martorell 106, 46026 Valencia, Spain

Leitat Technol Ctr, HEHS, Ave Fernando Abril Martorell 106, Valencia 46026, Spain

Instituto de Investigación. Hlth Res Inst La Fe, Unidad Analit, Ave Fernando Abril Martorell 106, Valencia 46026, Spain
Saugstad, OD:: Department of Pediatric Research, Institute for Surgical Research, University of Oslo, Oslo University Hospital - Rikshospitalet, Oslo, Norway

Univ Oslo, Oslo Univ Hosp, Rikshosp, Dept Pediat Res,Inst Surg Res, Oslo, Norway
Vento, M:: Instituto de Investigación. Neonatal Research Group, Health Research Institute Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, Spain

Division of Neonatology, University & Polytechnic Hospital La Fe, Avenida Fernando Abril Martorell 106, Valencia, Spain

Hlth Res Inst Hosp La Fe, Neonatal Res Grp, Ave Fernando Abril Martorell 106, Valencia, Spain

Univ & Polytech Hosp La Fe, Div Neonatol, Ave Fernando Abril Martorell 106, Valencia, Spain

Keywords

Hypoxia; Perinatal asphyxia; Newborn; Metabolic biomarker; Neonatal piglet model; Liquid Chromatography - Time-of-Flight Mass Spectrometry (LC-TOF-MS)