Portal de investigación
Clinical staging and serum cytokines in bipolar patients during euthymia
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Tatay-Manteiga, A
- Bristot, G
- Tabares-Seisdedos, R
- Kapczinski, F
- Cauli, O
Abstract
Aims: Changes in serum cytokines and altered neutrophin concentration have been associated with bipolar disorder (BD). Our aim here was to analyze peripheral blood biomarkers according to the clinical stages of BD. Method: Euthymic BD-I patients were grouped according to their level of functioning in early-stage (n = 25) and late-stage (n = 23), and compared to healthy siblings (n = 23) and genetically unrelated healthy controls (n = 21). Neurotrophin (neurotrophin-3 and BDNF) concentration and biomarkers of inflammation, including cytokines (IL-6, IL-10 and TNF-alpha), leukocytes count and acute phase proteins, were measured. Results: IL-10 concentration was significantly increased in early-stage patients compared to late-stage patients, healthy siblings and controls whereas TNF-alpha concentration was significantly increased in late-stage patients compared to controls. Total leukocytes, neutrophil and monocyte count were significantly increased in late-stage patients compared to healthy siblings and controls. The concentration of IL-6, neurotrophin-3 and BDNF was unchanged in euthymia. Healthy siblings did not show significant changes in any biomarker. Conclusions: The concentration of IL-10, TNF-alpha, neutrophil and monocytes subtype count in blood is altered in patients with BD during euthymic state. The link between peripheral inflammation and different stages in BD deserves further studies.
Datos de la publicación
- ISSN/ISSNe:
- 0278-5846, 1878-4216
- Tipo:
- Article
- Páginas:
- 194-201
- PubMed:
- 28445689
- Factor de Impacto:
- 1,714 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY PERGAMON-ELSEVIER SCIENCE LTD
Citas Recibidas en Web of Science: 25
Documentos
- No hay documentos
Filiaciones
Keywords
- Bipolar disorder; Cytokines; Inflammation; Neurotrophins; Leukocytes; Clinical staging
Proyectos y Estudios Clínicos
INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.
Investigador Principal: VICENT BALANZA MARTINEZ
PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017
Cita
Tatay A,BALANZA V,Bristot G,Tabares R,Kapczinski F,Cauli O. Clinical staging and serum cytokines in bipolar patients during euthymia. Prog Neuropsychopharmacol Biol Psychiatry. 2017. 77. p. 194-201. IF:4,185. (1).