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Mutational profile of primary breast diffuse large B-cell lymphoma

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Franco, F
  • Gonzalez-Rincon, J
  • Lavernia, J
  • Garcia, JF
  • Martin, P
  • Bellas, C
  • Piris, MA
  • Pedrosa, L
  • Miramon, J
  • Rodriguez-Abreu, D
  • Machado, I
  • Illueca, C
  • Alfaro, J
  • Provencio, M
  • Sanchez-Beato, M

Grupos

Abstract

Primary breast lymphoma is a rare form of extra-nodal lymphoid neoplasm. The most common histological type is the diffuse large B-cell lymphoma, which represents 60-80% of all the cases. Our study analyzes the mutational profile of the primary lymphoma of the breast through targeted massive sequencing with a panel of 38 genes in a group of 17 patients with primary breast diffuse large B-cell lymphoma. Seventy-point-five percent of the patients presented with stage IE and 29.5% with stage IIE. 44% of the cases correspond to lymphomas with germinal center phenotype and 33.3% to activated B-cell. The genes with a higher mutational frequency include PIM1 (in 50% of the analyzed samples), MYD88 (39%), CD79B, PRDM1 and CARD11 (17%), KMT2D, TNFIAP3 and CREBBP (11%). The profile of mutant genes involves mostly the NF kappa B signaling pathway. The high frequency of mutations in PIM1 compared with other lymphomas may have implications in the clinical presentation and evolution of this type of lymphoma.

Datos de la publicación

ISSN/ISSNe:
1949-2553, 1949-2553

Oncotarget  IMPACT JOURNALS LLC

Tipo:
Article
Páginas:
102888-102897
PubMed:
29262531
Factor de Impacto:
1,942 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 16

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Keywords

  • primary breast lymphoma; diffuse large B-cell lymphoma; cell of origin; NFkB pathway; PIM1

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