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A prospective multicenter cohort study of cutaneous melanoma: clinical staging and potential associations with HIF-1 alpha and VEGF expressions

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Riveiro-Falkenbach, E
  • Rodriguez-Peralto, JL
  • Nagore, E
  • Campos-Rodriguez, F
  • Farre, R
  • Hernández Blasco L
  • Bañuls Roca J
  • Chiner Vives E
  • Sanchez-de-la-Torre, A
  • Abad Capa J
  • Montserrat, JM
  • Almendros, I
  • Perez-Gil, A
  • Cabriada Nuño V
  • Cano-Pumarega, I
  • Corral Peñafiel J
  • Diaz Cambriles T
  • Mediano, O
  • Dalmau Arias J
  • Gozal, D
  • Spanish Sleep Network

Grupos

Abstract

Melanoma is a highly prevalent cancer that is associated with substantial mortality. Although clinical staging procedures can serve as relatively robust prognostic indicators, we aimed to determine whether assessments of the abundance of hypoxia inducible factor-1 alpha (HIF-1 alpha) or vascular endothelial growth factor (VEGF) in postexcisional melanoma tumor tissues may enable more accurate determination of tumor aggressiveness. We carried out a multicenter prospective study, in which we systematically evaluated 376 consecutive patients diagnosed with melanoma, and performed histochemical assessments for both HIF-1 alpha and VEGF immunoreactivity in the tumor biopsies. Multivariate analyses showed that higher HIF-1 alpha expression, but not high VEGF, were associated significantly and independently with increased tumor aggressiveness as derived from several well-established aggressiveness criteria. A limitation of this study was that this was a descriptive prospective study lacking a post-hoc verification arm. Thus, the presence of increased numbers of positively labeled HIF-1 alpha cells in melanoma tumors may potentially serve as an indicator of tumor phenotype and prognosis, and accordingly guide therapy. Copyright (C) 2017 Wolters Kluwer Health, Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0960-8931, 1473-5636

MELANOMA RESEARCH  LIPPINCOTT WILLIAMS & WILKINS

Tipo:
Article
Páginas:
558-564
PubMed:
28885396
Factor de Impacto:
1,259 SCImago ℠
Cuartil:
Q1 SCImago ℠

Citas Recibidas en Web of Science: 26

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Keywords

  • hypoxia-inducible factor; malignancy; melanoma; mitotic index; vascular endothelial growth factor

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