Portal de investigación
Frequency and prognostic significance of t(v;11q23)/KMT2A rearrangements in adult patients with acute lymphoblastic leukemia treated with risk-adapted protocols
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Motlló C
- Ribera JM
- Morgades M
- Granada I
- Brunet S
- Bergua J
- Tormo M
- García-Boyero R
- Sarrà J
- Del Potro E
- Grande C
- Barba P
- Bernal T
- Amigo ML
- Grau J
- Cervera J
- Feliu E
- PETHEMA Group, Spanish Society of Hematology
Grupos
Abstract
The karyotype is an important predictor of outcome in acute lymphoblastic leukemia (ALL). Rearrangements of the 11q23 region involving the KMT2A gene confer an unfavorable prognosis. Forty-six adult ALL patients from the PETHEMA Group treated with risk-adapted protocols, with t(v;11q23) were selected for this study. Complete response (CR) was attained in 38 patients; 25 remained in CR after consolidation. Twelve (48%) received allogeneic hematopoietic stem cell transplantation (HSCT) and 13 delayed intensification and maintenance. The 5-year CR duration probability was 37% (95% CI, 19%-55%). A trend for a longer CR duration was observed in patients undergoing HSCT vs. those receiving chemotherapy. The 5-year overall survival (OS) probability was 20% (95% CI, 5%-35%). The OS was better, albeit not significant, in patients with a MRD level< 0.1% after induction (39% [95% CI, 14%-64%] vs. 13% [95% CI, 0%-36%]). Specific treatment approaches are required to improve the outcome of patients with KMT2A-rearrangements.
Datos de la publicación
- ISSN/ISSNe:
- 1042-8194, 1029-2403
- Tipo:
- Article
- Páginas:
- 145-152
- PubMed:
- 27122129
- Factor de Impacto:
- 0,976 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
LEUKEMIA & LYMPHOMA TAYLOR & FRANCIS LTD
Citas Recibidas en Web of Science: 11
Documentos
- No hay documentos
Filiaciones
Keywords
- KMT2A/MLL; acute lymphoblastic leukemia; MRD