Use of Dexmedetomidine in Cardiothoracic and Vascular Anesthesia

Fecha de publicación: 01/06/2018 Fecha Ahead of Print: 02/12/2017

Autores de IIS La Fe

María Azucena Pajares Moncho

Autor

Participantes ajenos a IIS La Fe

Gallego-Ligorit, L
Vives, M
Valles-Torres, J
Sanjuan-Villarreal, TA
Iglesias, M

Grupos

Anestesia y Cuidados Críticos

Investigador Principal

María Azucena Pajares Moncho
Medicina Perioperatoria, Anestesiología y Reanimación

Leader

Óscar Díaz Cambronero

Abstract

Dexmedetomidine is a highly selective alpha(2)-adrenergic agonist with analgesic and sedative properties. In the United States, the Food and Drug Administration approved the use of the drug for short-lasting sedation (24 h) in intensive care units (ICUs) in patients undergoing mechanical ventilation and endotracheal intubation. In October 2008, the Food and Drug Administration extended use of the drug for the sedation of nonintubated patients before and during surgical and nonsurgical procedures. In the European Union, the European Medicine Agency approved the use of dexmedetomidine in September 2011 with a single recognized indication: ICU adult patients requiring mild sedation and awakening in response to verbal stimulus. At present, the use of dexmedetomidine for sedation outside the ICU remains an off-label indication. The benefits of dexmedetomidine in critically ill patients and in cardiac, electrophysiology-related, vascular, and thoracic procedures are discussed. (C) 2017 Elsevier Inc. All rights reserved.

Datos de la publicación

ISSN/ISSNe:: 1053-0770, 1532-8422
Tipo:: Review
Páginas:: 1426-1438
DOI:: 10.1053/j.jvca.2017.11.044
PubMed:: 29325842
Factor de Impacto:: 0,592 SCImago ℠
Cuartil:: Q2 SCImago ℠

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Métricas

Filiaciones

Gallego-Ligorit, L:: Department of Anesthesiology and Critical Care Medicine, Cardiovascular and Thoracic Anesthesia Section,Hospital Universitario Miguel Servet, Zaragoza, Spain

Hosp Univ Miguel Servet, Dept Anesthesiol & Crit Care Med, Cardiovasc & Thorac Anesthesia Sect, Zaragoza, Spain
Vives, M:: Department of Anesthesiology and Critical Care Medicine, Hospital de Bellvitge, Barcelona, Spain

Hosp Bellvitge Princeps Espanya, Dept Anesthesiol & Crit Care Med, Barcelona, Spain
Valles-Torres, J:: Department of Anesthesiology and Critical Care Medicine, Cardiovascular and Thoracic Anesthesia Section,Hospital Universitario Miguel Servet, Zaragoza, Spain

Hosp Univ Miguel Servet, Dept Anesthesiol & Crit Care Med, Cardiovasc & Thorac Anesthesia Sect, Zaragoza, Spain
Sanjuan-Villarreal, TA:: Department of Anesthesiology and Critical Care Medicine, Cardiovascular and Thoracic Anesthesia Section,Hospital Universitario Miguel Servet, Zaragoza, Spain

Hosp Univ Miguel Servet, Dept Anesthesiol & Crit Care Med, Cardiovasc & Thorac Anesthesia Sect, Zaragoza, Spain
Pajares, A:: Department of Anesthesiology and Critical Care Medicine, Cardiovascular and Thoracic Anesthesia Section,Hospital Universitari i Politecnic La Fe, Valencia, Spain

Hosp Univ & Politecn La Fe, Dept Anesthesiol & Crit Care Med, Cardiovasc & Thorac Anesthesia Sect, Valencia, Spain
Iglesias, M:: Department of Anesthesiology and Reanimation, Hospital General Universitario Gregorio Marañón, Madrid, Spain

Instituto de Investigación Sanitaria Gregorio Marañón. (IiSGM), Madrid, Spain

Hosp Gen Univ Gregorio Maranon, Dept Anesthesiol & Reanimat, Madrid, Spain

IiSGM, Madrid, Spain

Keywords

Dexmedetomidine sedation; cardiothoracic and vascular anesthesia; delirium; cardiac catheterization laboratory and electrophysiology (EP)-related procedures sedation