Portal de investigación
Gender differences in C-reactive protein and homocysteine modulation of cognitive performance and real-world functioning in bipolar disorder
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Sanchez-Autet, M
- Arranz, B
- Safont, G
- de la Fuente, L
- Garriga, M
- Garcia-Portilla, MP
Grupos
Abstract
Background: Cognitive and psychosocial impairment has been associated with increased levels of C-reactive protein (CRP) and homocysteine in bipolar disorder, but gender differences have seldom been studied. Methods: Two hundred and twenty-four bipolar outpatients were included. Cognitive performance was assessed through the Screen for Cognitive Impairment in Psychiatry (SCIP). Psychosocial functioning was evaluated using the Functioning Assessment Short Test (FAST) and the General Assessment of Functioning (GAF). Homocysteine and CRP levels were determined. Separate analyses were performed by gender. Partial correlations were calculated to test for associations between biomarkers and cognitive and psychosocial functioning. Hierarchical multiple regression was used to assess factors predicting cognitive and psychosocial functioning. Covariates were: age, education, duration of illness, hospital admissions, depressive symptoms, tobacco consumption, and BMI. Results: A better performance was noted in women in delayed verbal learning (p = 0.010), along with better occupational functioning (p = 0.027) and greater leisure time impairment (p = 0.034). In men, CRP and homocysteine levels were associated with psychosocial dysfunction (interpersonal relationships and financial functioning, respectively). In women, CRP levels correlated with cognitive performance (SCIP total raw score, immediate and delayed verbal learning, and verbal fluency). CRP was a predictor of cognitive performance in women only. Limitations: The choice of the cognitive scale and covariates and the lack of a control group may be the main limitations. Conclusions: A gender difference was found in biomarker modulation of cognition and psychosocial functioning. A gender-based approach to cognition and real-world functioning should be considered in bipolar disorder to ensure an optimal outcome.
Datos de la publicación
- ISSN/ISSNe:
- 0165-0327, 1573-2517
- Tipo:
- Article
- Páginas:
- 95-104
- Factor de Impacto:
- 1,873 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
JOURNAL OF AFFECTIVE DISORDERS ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 21
Documentos
- No hay documentos
Filiaciones
Keywords
- MAJOR DEPRESSIVE DISORDER; I DISORDER; INTERNATIONAL SOCIETY; CYTOKINE LEVELS; SEX-DIFFERENCES; IMPAIRMENT; SCHIZOPHRENIA; NEUROPROGRESSION; ASSOCIATION; SCALE
Proyectos asociados
EFECTOS DE LA MONOTERAPIA CON LITIO EN EL FUNCIONAMIENTO NEUROPSICOLOGICO DE LOS PACIENTES CON TRASTORNO BIPOLAR
Investigador Principal: LORENZO LIVIANOS ALDANA
SM I 22/2011 . 2012
CARACTERIZACIÓN EPIGENÓMICA DE LA ANOREXIA NERVIOSA. MODELO DE GEMELAS MONOCIGOTAS DISCORDANTES Y VALIDACIÓN EN POBLACIÓN GENERAL.
Investigador Principal: LUIS MIGUEL ROJO MORENO
PI16/01279 . INSTITUTO DE SALUD CARLOS III . 2017
INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.
Investigador Principal: VICENT BALANZA MARTINEZ
PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017
RED DE SALUD MATERNO-INFANTIL Y DEL DESARROLLO.
Investigador Principal: MÁXIMO VENTO TORRES
RD16/0022/0001 . INSTITUTO DE SALUD CARLOS III . 2017
COMPRENSIÓN DEL LENGUAJE FIGURATIVO Y ANÁFORAS EN LECTORES CON TRASTORNOS DEL ESPECTRO AUTISTA DESARROLLO: ESTUDIO DE MOVIMIENTOS OCULARES Y POTENCIALES EVOCADOS.
Investigador Principal: INMACULADA FAJARDO BRAVO
AICO/2016 . 2016
Contrato Juan Rodés (Ana Cristina García Blanco)
Investigador Principal: ANA CRISTINA GARCÍA BLANCO
JR17/00003 . INSTITUTO DE SALUD CARLOS III . 2018
Validación de biomarcadores de daño neurológico en prematuros con episodios de hipoxia intermitente.
Investigador Principal: MARÍA ISABEL TORRES CUEVAS
GV/2018/021 . CONSELLERIA DE EDUCACION . 2018
TREATMENT-RESISTANT DEPRESSION COHORT IN EUROPE.
Investigador Principal: PILAR SIERRA SAN MIGUEL
JAN-ANT-2017-01 . 2018
Cita
Sanchez M,Arranz B,Safont G,Sierra P,Garcia A,de la Fuente L,Garriga M,Garcia MP. Gender differences in C-reactive protein and homocysteine modulation of cognitive performance and real-world functioning in bipolar disorder. J Affect Disord. 2018. 229. p. 95-104. IF:4,084. (1).