Manic espisode, confusional syndrome and reversible splenial lesion after abrupt withdrawal of oxcarbazepine

Fecha de publicación:

Autores de IIS La Fe

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Abstract

Background: Anticonvulsants are considered a second line option for bipolar disorder, it is known that the abrupt withdrawal is rarely related with demyelinated lesions of the splenium of the corpus callosum. Oxcarbazepine is used in bipolar disorder although it is not stated in the data sheet. Clinical case:: We presented a case of a 50 years old woman with bipolar disorder who is treated with lithium and oxcarbazepine, she presented a manic episode and a confusional syndrome after she stopped taking the medication. The magnetic resonance showed a restricted diffusion area at the splenium of the corpus callosum and bifrontal hygromas that disappear two weeks later. Conclusions: The results of this study suggest that for a patient presenting with a mild encephalopathy and reversible splenial lesion, one should consider whether it is related to withdrawal of oxcarbazepine.

Datos de la publicación

ISSN/ISSNe:
0165-0327, 1573-2517

JOURNAL OF AFFECTIVE DISORDERS  ELSEVIER SCIENCE BV

Tipo:
Editorial Material
Páginas:
122-124
PubMed:
28027511
Factor de Impacto:
2,053 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 3

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Keywords

  • Oxcarbazepine; Manic episode; Bipolar disease; Encephalopathy

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