Manic espisode, confusional syndrome and reversible splenial lesion after abrupt withdrawal of oxcarbazepine

Autors de IIS La Fe

• Milton Henry Merizalde Torres

  Autor

• Pablo Navalón Rodríguez

  Autor

• María Fernanda González Romero

  Autor

• Alberto Domínguez Carabantes

  Autor

• Lorenzo Livianos Aldana

  Autor

• Juan Carlos Martinez Escoriza

  Autor

Grups d'Investigació

• Investigación en Salud Mental

  

  Leader

  Ana Cristina García Blanco

Abstract

Background: Anticonvulsants are considered a second line option for bipolar disorder, it is known that the abrupt withdrawal is rarely related with demyelinated lesions of the splenium of the corpus callosum. Oxcarbazepine is used in bipolar disorder although it is not stated in the data sheet. Clinical case:: We presented a case of a 50 years old woman with bipolar disorder who is treated with lithium and oxcarbazepine, she presented a manic episode and a confusional syndrome after she stopped taking the medication. The magnetic resonance showed a restricted diffusion area at the splenium of the corpus callosum and bifrontal hygromas that disappear two weeks later. Conclusions: The results of this study suggest that for a patient presenting with a mild encephalopathy and reversible splenial lesion, one should consider whether it is related to withdrawal of oxcarbazepine.

Keywords

• Oxcarbazepine; Manic episode; Bipolar disease; Encephalopathy