Portal de investigación
Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Moreno-Navarrete, JM
- Blasco, G
- Puig, J
- Biarnes, C
- Rivero, M
- Gich, J
- Fernandez-Aranda, F
- Garre-Olmo, J
- Rami-Torrenta, L
- Pedraza, S
- Ricart, W
- Fernandez-Real, JM
Grupos
Abstract
BACKGROUND/ OBJECTIVES: Growing evidence implicates neuroinflammation in the pathogenesis of diet-induced obesity and cognitive dysfunction in rodent models. Obesity is associated with reduced white matter integrity and cognitive decline. Circulating lipopolysaccharide binding protein (LBP) concentration is known to be increased in patients with obesity. Here, we aimed to evaluate whether circulating LBP is associated longitudinally with white matter structure and cognitive performance according to obesity status. SUBJECTS/METHODS: This longitudinal study analyzed circulating LBP (ELISA), DTI-metrics (axial diffusivity (L1), fractional anisotropy (FA) and radial diffusivity (RD)) in specific regions of the white matter of 24 consecutive middle-aged obese subjects (13 women) and 20 healthy volunteers (10 women) at baseline and two years later. Digit Span Test (DST) was used as a measure of working memory/short-term verbal memory. RESULTS: Circulating LBP concentration was associated with FA and L1 values of several white matter regions both at baseline and follow-up. The associations remained significant after controlling for age, BMI, fat mass and plasma high sensitivity C-reactive protein. Importantly, the increase in LBP over time impacted negatively on FA and L1 values and on DST performance. CONCLUSIONS: Circulating LBP associates with brain white matter integrity and working memory/short-term verbal memory in both obese and non-obese subjects.
Datos de la publicación
- ISSN/ISSNe:
- 0307-0565, 1476-5497
- Tipo:
- Article
- Páginas:
- 1627-1635
- DOI:
- 10.1038/ijo.2017.162
- PubMed:
- 28684860
- Factor de Impacto:
- 2,650 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
INTERNATIONAL JOURNAL OF OBESITY NATURE PUBLISHING GROUP
Citas Recibidas en Web of Science: 28
Documentos
- No hay documentos
Filiaciones
Proyectos y Estudios Clínicos
PATRONES DE RM CEREBRAL Y MEDULAR EN RELACION CON LA PRESENCIA DE AUTOANTIGENOS NEURONALES RECONOCIDOS POR INMUNOGLOBULINAS M PRESENTES EN EL LIQUIDO CEFALORRAQUIDEO DE PACIENTES DE ESCLEROSIS MULTIPLE.
Investigador Principal: ISABEL BOSCÁ BLASCO
MERCK SERONO DR. CASANOVA . ALMIRALL S.A; FUNDACIÓN BIOGEN IDEC; MERCK S.L.U; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2010
CONTROL Y SEGUIMIENTO INTEGRAL DE LA RADIACIÓN IONIZANTE RECIBIDA TRAS EXPLORACIONES MÉDICAS: COSIRI.
Investigador Principal: ÁNGEL ALBERICH BAYARRI
GV/2015/132 . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; CONSELLERIA DE EDUCACION . 2015
PREMICAT. DESARROLO DE UNA ESTRATEGIA PARA LA PREVENCION MIOCARDICA DEL DAÑO INDUCIDO POR REPERFUSION BASADA EN EL USO DE CATETERES Y POLIMEROS TARAPEUTICOS DE NUEVA GENERACION.
Investigador Principal: PILAR SEPÚLVEDA SANCHIS
DTS15/00079 . INSTITUTO DE SALUD CARLOS III . 2016
TERAPIA CELULAR DESPUES DEL ICTUS DIRIGIDA MEDIANTE CAMPOS MAGNETICOS. APLICACION DE RM-TDI Y TRACTOGRAFIA CEREBRAL EN ICTUS PARA LA VALORACION DEL DAÑO NEUROLOGICO
Investigador Principal: JOSÉ MANUEL GARCÍA VERDUGO
2015_0534_GARCIA_VERDUGO_MAPFRE . 2015
DISEÑO Y DESARROLLO DE UNA PLATAFORMA MULTIESCALA-IN VITRO-IN VIVO PARA LA PREVENCIÓN DE LA FRACTURA ÓSEA OSTEOPORÓTICA MEDIANTE CEMENTACIÓN FEMORAL: UNA HERRAMIENTA PRECLÍNICA
Investigador Principal: ÁNGEL ALBERICH BAYARRI
DPI2014-53401-C2-2-R . MINISTERIO DE ECONOMIA Y COMPETITIVIDAD; FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2015
Cita
Moreno JM,Blasco G,Puig J,Biarnes C,Rivero M,Gich J,Fernandez F,Garre J,Rami L,ALBERICH A,GARCIA F,Pedraza S,Ricart W,Fernandez JM. Neuroinflammation in obesity: circulating lipopolysaccharide-binding protein associates with brain structure and cognitive performance. Int J Obes (Lond). 2017. 41. (11):p. 1627-1635. IF:5,151. (1).