Portal de investigación
Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation
Fecha de publicación:
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Trompier, F
- Baumann, M
- Barrios, L
- Gregoire, E
- Abend, M
- Ainsbury, E
- Barnard, S
- Barquinero, JF
- Bautista, JA
- Brzozowska, B
- De Angelis, C
- Dominguez, I
- Hadjidekova, V
- Kulka, U
- Mateos, JC
- Meschini, R
- Monteiro Gil O
- Moquet, J
- Oestreicher, U
- Quintens, R
- Sommer, S
- Stoyanov, O
- Thierens, H
- Terzoudi, G
- Vral, A
- Wojcik, A
- Zafiropoulos, D
- Roy, L
Grupos
Abstract
Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.
Datos de la publicación
- ISSN/ISSNe:
- 0955-3002, 1362-3095
- Tipo:
- Article
- Páginas:
- 118-126
- Factor de Impacto:
- 0,653 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY TAYLOR & FRANCIS LTD
Citas Recibidas en Web of Science: 17
Documentos
- No hay documentos
Filiaciones
Keywords
- Alanine dosimetry; biological dosimetry; calibration; inter-laboratory comparison; quality assurance
Proyectos asociados
REALIZING THE EUROPEAN NETWORK IN BIODOSIMETRY (RENEB)
295513_RENEB_PE_MONTORO_FP7-Fission-2011 . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA . 2012
CONTROL Y SEGUIMIENTO INTEGRAL DE LA RADIACIÓN IONIZANTE RECIBIDA TRAS EXPLORACIONES MÉDICAS: COSIRI.
Investigador Principal: ÁNGEL ALBERICH BAYARRI
GV/2015/132 . FUNDACIÓN PARA LA INVESTIGACIÓN DEL HOSPITAL UNIVERSITARIO LA FE DE LA COMUNIDAD VALENCIANA; CONSELLERIA DE EDUCACION . 2015
ESTUDIO DE BRAQUITERAPIA ELECTRÓNICA PARA CARCINOMA CUTÁNEO BASOCELULAR.
Investigador Principal: JOSÉ PÉREZ CALATAYUD
BCCBRACHY
Cita
Trompier F,Baumann M,Barrios L,Gregoire E,Abend M,Ainsbury E,Barnard S,Barquinero JF,Bautista JA,Brzozowska B,Perez J,De Angelis C,Dominguez I,Hadjidekova V,Kulka U,Mateos JC,Meschini R,Monteiro O,Moquet J,Oestreicher U,Montoro A,Quintens R,Sebastia N,Sommer S,Stoyanov O,Thierens H,Terzoudi G,Villaescusa JI,Vral A,Wojcik A,Zafiropoulos D,Roy L. Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation. Int J Radiat Biol. 2017. 93. (1):p. 118-126. IF:1,970. (1).