Do patients with bipolar disorder and subsyndromal symptoms benefit from functional remediation? A 12-month follow-up study

Fecha de publicación:

Autores de IIS La Fe

Participantes ajenos a IIS La Fe

  • Sanchez-Moreno, J
  • Bonnin, C
  • Gonzalez-Pinto, A
  • Amann, BL
  • Sole, B
  • Arango, C
  • Jimenez, E
  • Tabares-Seisdedos, R
  • Garcia-Portilla, MP
  • Ibáñez A
  • Crespo, JM
  • Ayuso-Mateos, JL
  • Vieta, E
  • Martinez-Aran, A
  • Torrent, C
  • CIBERSAM Functional Remediation Group

Abstract

We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to DSM-IV-TR diagnostic criteria, entering a randomized clinical trial, those patients who presented with subsyndromal symptoms were selected based on a method already described by Berk and colleagues was applied. It consists of using the Clinical Global Impression-Bipolar version (CGI-BP) to establish the scores of the Hamilton Depression Rating Scale (HAM-D) and of the Young Mania Rating Scale (YMRS) that correspond with 1 in the CGI-BP. Functional outcome and mood symptoms were assessed at 6 and at 12 month follow-up. A total of 99 patients were selected for this post-hoc analysis, allocated as follows: functional remediation (n=33); psychoeducation (n=37) and treatment as usual (TAU,n=29). The repeated-measures analyses at 12-month follow-up revealed a significant group x time interaction in favour of the patients who received functional remediation when compared to psychoeducation and TAU (F=2.93; p=0.02) at improving psychosocial functioning. Finally, mood symptoms did not significantly change in any of the three groups at any time of follow-up, as shown by the non-significant group x time interaction effect in HAM-D scores (F=1.57; p=0.18) and YMRS scores (F=1.51; p=0.20). Bipolar patients with subsyndromal symptoms improve their functional outcome when exposed to functional remediation regardless of the persistence of mood symptomatology. (C) 2017 Elsevier B.V. and ECNP. All rights reserved.

Datos de la publicación

ISSN/ISSNe:
0924-977X, 1873-7862

EUROPEAN NEUROPSYCHOPHARMACOLOGY  ELSEVIER SCIENCE BV

Tipo:
Article
Páginas:
350-359
PubMed:
28126401
Factor de Impacto:
1,911 SCImago
Cuartil:
Q1 SCImago

Citas Recibidas en Web of Science: 18

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Keywords

  • Bipolar disorder; Functional remediation; Subsyndromal symptoms; Treatment

Campos de Estudio

Proyectos y Estudios Clínicos

INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.

Investigador Principal: VICENT BALANZA MARTINEZ

PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017

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