Do patients with bipolar disorder and subsyndromal symptoms benefit from functional remediation? A 12-month follow-up study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Sanchez-Moreno, J
- Bonnin, C
- Gonzalez-Pinto, A
- Amann, BL
- Sole, B
- Arango, C
- Jimenez, E
- Tabares-Seisdedos, R
- Garcia-Portilla, MP
- Ibáñez A
- Crespo, JM
- Ayuso-Mateos, JL
- Vieta, E
- Martinez-Aran, A
- Torrent, C
- CIBERSAM Functional Remediation Group
Abstract
We analyzed the efficacy of functional remediation, in a sample of patients with bipolar disorder who presented with subsyndromal symptoms. From a total sample of 239 patients with bipolar I and II disorder, according to DSM-IV-TR diagnostic criteria, entering a randomized clinical trial, those patients who presented with subsyndromal symptoms were selected based on a method already described by Berk and colleagues was applied. It consists of using the Clinical Global Impression-Bipolar version (CGI-BP) to establish the scores of the Hamilton Depression Rating Scale (HAM-D) and of the Young Mania Rating Scale (YMRS) that correspond with 1 in the CGI-BP. Functional outcome and mood symptoms were assessed at 6 and at 12 month follow-up. A total of 99 patients were selected for this post-hoc analysis, allocated as follows: functional remediation (n=33); psychoeducation (n=37) and treatment as usual (TAU,n=29). The repeated-measures analyses at 12-month follow-up revealed a significant group x time interaction in favour of the patients who received functional remediation when compared to psychoeducation and TAU (F=2.93; p=0.02) at improving psychosocial functioning. Finally, mood symptoms did not significantly change in any of the three groups at any time of follow-up, as shown by the non-significant group x time interaction effect in HAM-D scores (F=1.57; p=0.18) and YMRS scores (F=1.51; p=0.20). Bipolar patients with subsyndromal symptoms improve their functional outcome when exposed to functional remediation regardless of the persistence of mood symptomatology. (C) 2017 Elsevier B.V. and ECNP. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0924-977X, 1873-7862
- Tipo:
- Article
- Páginas:
- 350-359
- PubMed:
- 28126401
- Factor de Impacto:
- 1,911 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
EUROPEAN NEUROPSYCHOPHARMACOLOGY ELSEVIER SCIENCE BV
Citas Recibidas en Web of Science: 18
Documentos
- No hay documentos
Filiaciones
Keywords
- Bipolar disorder; Functional remediation; Subsyndromal symptoms; Treatment
Proyectos y Estudios Clínicos
INFLAMACIÓN, DISBIOSIS Y TRASLOCACIÓN BACTERIANA EN TRASTORNO BIPOLAR Y ESQUIZOFRENIA: INFLUENCIA DEL ESTILO DE VIDA. ESTUDIO PROBILIFE.
Investigador Principal: VICENT BALANZA MARTINEZ
PI16/01770 . INSTITUTO DE SALUD CARLOS III . 2017
Cita
Sanchez J,Bonnin C,Gonzalez A,Amann BL,Sole B,BALANZA V,Arango C,Jimenez E,Tabares R,Garcia MP,Ibáñez A,Crespo JM,Ayuso JL,Vieta E,Martinez A,Torrent C,CIBERSAM Functional Remediation G. Do patients with bipolar disorder and subsyndromal symptoms benefit from functional remediation? A 12-month follow-up study. Eur. Neuropsychopharmacol. 2017. 27. (4):p. 350-359. IF:4,129. (1).