Portal de investigación
Long-term outcomes in ypT0 rectal cancers: An international multi-centric investigation on behalf of Italian Society of Surgical Oncology Young Board (YSICO)
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Lorenzon L
- Parini D
- Rega D
- Mellano A
- Vigorita V
- Biondi A
- Jaminez-Rosellon R
- Scheiterle M
- Giannini I
- Gallo G
- Marino G
- Turati L
- Marsanic P
- De Franco L
- Marano L
- De Luca R
Grupos
Abstract
Aim: To investigate the outcome and pattern of survivals of rectal cancer patients presenting a complete or nearly complete tumor response after neo-adjuvant treatment. Methods: Young surgeons <40 years old affiliated to the Italian Society of Surgical Oncology (YSICO) from 13 referral centers for colorectal cancer treatment, were invited to participate a retrospective study. Records from patients treated from 2005 to 2015 with a pathological diagnosis of ypT0/ypTis were retrieved and pooled in a common data-base for statistical purposes. All clinical and pathological variables were reviewed. Univariate and multivariate analyses were conducted with the end-point of survivals. Results: Two hundreds and sixty-one patients were analyzed including 237 ypT0 and 24 ypTis. Nodal positive patients were 8.7%. More than sixty-six percent of the patients did not perform adjuvant chemotherapy, with a statistical difference comparing N0 patients (66.8% vs 40.9%, p 0.02). Mean follow-up was of 47.6 months. Twenty-two relapses were observed, 91.6% at a distant site. The mean time to recurrence was of 35.3 months. On univariate analysis, the use of adjuvant chemotherapy correlated with better OS exclusively inypT0N + patients and not in ypT0N0. Univariate and multivariate analyses documented nodal positivity as the only prognostic factor correlated with a worse OS. Conclusion: Recurrences were mostly diagnosed at a distant site and within the third year of follow-up. Nodal positivity was the only variable independently correlated with a worse OS. Univariate analysis documented a benefit for the use of adjuvant chemotherapy treatment exclusively in ypT0N + rectal cancers. (C) 2017 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.
Datos de la publicación
- ISSN/ISSNe:
- 0748-7983, 1532-2157
- Tipo:
- Article
- Páginas:
- 1472-1480
- Factor de Impacto:
- 1,466 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
EJSO ELSEVIER SCI LTD
Citas Recibidas en Web of Science: 9
Documentos
- No hay documentos
Filiaciones
Keywords
- Rectal cancer; Neo-adjuvant treatment; Pathologic complete response; ypT0
Proyectos asociados
WIBEC. WIRELESS IN-BODY ENVIRONMENT COMMUNICATIONS.
Investigador Principal: VICENTE PONS BELTRÁN
675353 . COMISION EUROPEA . 2016
Cita
Lorenzon L,Parini D,Rega D,Mellano A,Vigorita V,Biondi A,Jaminez R,Scheiterle M,Giannini I,Gallo G,Marino G,Turati L,Marsanic P,De Franco L,Marano L,Senior SICO Supervising M,De Luca R. Long-term outcomes in ypT0 rectal cancers: An international multi-centric investigation on behalf of Italian Society of Surgical Oncology Young Board (YSICO). Eur J Surg Oncol. 2017. 43. (8):p. 1472-1480. IF:3,688. (1).