Portal de investigación
Vernakalant in hospital emergency practice: safety and effectiveness
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Carbajosa Dalmau J
- Nocedas, J
- Urtubia-Palacios, A
- Hernandez-Sori, N
- Peiro-Gomez, A
- Jacob, J
- Llorens, P
- Ruescas-Gomez, L
- Martin-Martinez, A
Grupos
Abstract
Objectives. To study the effectiveness and safety of vernakalant for restoration of sinus rhythm in patients with atrial fibrillation (AF) in routine hospital emergency department care, and to evaluate factors associated with a more effective response. Methods. Prospective multicenter cohort study enrolling consecutive patients who were administered vernakalant for medical cardioversion of AF between September 2014 through March 2016 in 5 hospitals in the Spanish autonomous community of Valencia. Results. We studied 165 cases. The median (interquartile range) was 68 years (56-77) years. Cardioversion with vernakalant was effective in 77.6% (95% CI, 71.1%-84%). The median time to conversion was 8 ( 6-12) minutes after a first dose and 34 (22-62) minutes after a second dose. A prior history of cardiac insufficiency was nonsignificantly less common in patients who converted with vernakalant (6.3%) than in those who did not (18.9%) (adjusted odds ratio [OR], 0.45 [95% CI, 0.13-1.56]; P=.208). Having no prior history of AF was nonsignificantly related to greater effectiveness (in 54.7% vs in 35.1% with prior AF). Duration less than 12 hours was significantly associated with greater effectiveness (83.6% vs 59.5%; adjusted OR, 2.76 [95% CI, 1.12-6.80]; P=.028). Adverse events were reported for 30 patients. None of the events had clinically important consequences, and in only 2 cases (1.2%) was it necessary to suspend treatment. Conclusion. Vernakalant is effective and safe for restoring sinus rhythm in the hospital emergency department.
Datos de la publicación
- ISSN/ISSNe:
- 1137-6821, 2386-5857
- Tipo:
- Article
- Páginas:
- 397-402
- PubMed:
- 29188914
- Factor de Impacto:
- 0,603 SCImago ℠
- Cuartil:
- Q2 SCImago ℠
EMERGENCIAS SANIDAD EDICIONES
Citas Recibidas en Web of Science: 12
Documentos
- No hay documentos
Métricas
Filiaciones
Keywords
- Atrial fibrillation; Cardioversion; Vernakalant; Emergency health services
Proyectos y Estudios Clínicos
EFECTO DE V0251 EN EL VÉRTIGO AGUDO. ESTUDIO ALEATORIZADO, DOBLE CIEGO Y CONTROLADO CON PLACEBO.
Investigador Principal: HERMINIO PÉREZ GARRIGUES
V00251IV2024A
Cita
Carbajosa J,COSIN J,PEREZ MJ,Nocedas J,Urtubia A,Hernandez N,Peiro A,Jacob J,Llorens P,Ruescas L,Martin A. Vernakalant in hospital emergency practice: safety and effectiveness. Emergencias. 2017. 29. (6):p. 397-402. IF:3,608. (1).