Portal de investigación
First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study
Autores de IIS La Fe
Participantes ajenos a IIS La Fe
- Rubio-Rivas M
- Corbella X
- Pestaña-Fernández M
- Tolosa-Vilella C
- Guillen-Del Castillo A
- Colunga-Argüelles D
- Trapiella-Martínez L
- Iniesta-Arandia N
- Castillo-Palma MJ
- Sáez-Comet L
- Egurbide-Arberas MV
- Ortego-Centeno N
- Freire M
- Vargas-Hitos JA
- Ríos-Blanco JJ
- Rodríguez-Carballeira M
- Marín-Ballvé A
- Segovia-Alonso P
- Pla-Salas X
- Madroñero-Vuelta AB
- Ruiz-Muñoz M
- Fonollosa-Pla V
- Simeón-Aznar CP
- RESCLE investigators, Autoimmune Diseases Study Group (GEAS)
- Callejas Moraga E
- Calvo E
- Carbonell C
- Castillo MJ
- Chamorro AJ
- Colunga D
- Corbella X
- Egurbide MV
- Espinosa G
- Fonollosa V
- Freire M
- García Hernández FJ
- González León R
- Guillén Del Castillo A
- Iniesta N
- Lorenzo R
- Madroñero AB
- Marí B
- Marín A
- Ortego-Centeno N
- Pérez Conesa M
- Pestaña M
- Pla X
- Ríos Blanco JJ
- Rodríguez Carballeira M
- Rubio Rivas M
- Ruiz Muñoz M
- Sáez Comet L
- Segovia P
- Simeón CP
- Soto A
- Tarí E
- Tolosa C
- Trapiella L
- Vargas Hitos JA
- Verdejo G
Grupos
Abstract
The objective of the study is to determine the importance of the mode of onset as prognostic factor in systemic sclerosis (SSc). Data were collected from the Spanish Scleroderma Registry (RESCLE), a nationwide retrospective multicenter database created in 2006. As first symptom, we included Raynaud's phenomenon (RP), cutaneous sclerosis, arthralgia/arthritis, puffy hands, interstitial lung disease (ILD), pulmonary arterial hypertension (PAH), and digestive hypomotility. A total of 1625 patients were recruited. One thousand three hundred forty-two patients (83%) presented with RP as first symptom and 283 patients (17%) did not. Survival from first symptom in those patients with RP mode of onset was higher at any time than those with onset as non-Raynaud's phenomenon: 97 vs. 90% at 5 years, 93 vs. 82% at 10 years, 83 vs. 62% at 20 years, and 71 vs. 50% at 30 years (p < 0.001). In multivariate analysis, factors related to mortality were older age at onset, male gender, dcSSc subset, ILD, PAH, scleroderma renal crisis (SRC), heart involvement, and the mode of onset with non-Raynaud's phenomenon, especially in the form of puffy hands or pulmonary involvement. The mode of onset should be considered an independent prognostic factor in systemic sclerosis and, in particular, patients who initially present with non-Raynaud's phenomenon may be considered of poor prognosis.
Datos de la publicación
- ISSN/ISSNe:
- 0770-3198, 1434-9949
- Tipo:
- Article
- Páginas:
- 999-1009
- PubMed:
- 29214548
- Factor de Impacto:
- 0,948 SCImago ℠
- Cuartil:
- Q1 SCImago ℠
CLINICAL RHEUMATOLOGY SPRINGER LONDON LTD
Citas Recibidas en Web of Science: 25
Documentos
- No hay documentos
Filiaciones
Keywords
- Onset; Prognosis; Raynaud; Scleroderma; Systemic sclerosis
Proyectos y Estudios Clínicos
ENSAYO MULTICÉNTRICO, ABIERTO Y CON UN SOLO GRUPO PARA EVALUAR LA EFICACIA, LA FARMACOCINÉTICA, LA SEGURIDAD Y LA TOLERABILIDAD DE IGSC AL 20 % EN SUJETOS CON INMUNODEFICIENCIA PRIMARIA.
Investigador Principal: PEDRO MORAL MORAL
GTI 1503 . 2017
PREVENCIÓN DE EPISODIOS DE TROMBOEMBOLIA - REGISTRO EUROPEO SOBRE TROMBOEMBOLIA VENOSA.
Investigador Principal: JOSÉ ANTONIO TODOLÍ PARRA
DAI-VTE-2013-02 . 2014
ENSAYO CLINICO FASE III, DE GRUPOS PARALELOS, RANDOMIZADO, CONTROLADO CON PLACEBO, DOBLE CIEGO Y MULTICENTRICO, PARA EVALUAR LA EFICACIA Y SEGURIDAD DE LA ADMINISTRACION DE TOCILIZUMAB EN PACIENTES DIAGNOSTICADOS DE ORBITOPATÍA TIROIDEA (OT) MODERADA A SE VERA O QUE AMENAZA LA VISTA, QUE NO HAN RESPONDIDO ADECUADAMENTE AL TRATAMIENTO CON PULSOS DE CORTICOIDES.
Investigador Principal: ENRIQUE ESPAÑA GREGORI
GRC-TCL-2010-01 . 2013
Cita
Rubio M,Corbella X,Pestaña M,Tolosa C,Guillen A,Colunga D,Trapiella L,Iniesta N,Castillo MJ,Sáez L,Egurbide MV,Ortego N,Freire M,Vargas JA,Ríos JJ,TODOLÍ JA,Rodríguez M,Marín A,Segovia P,Pla X,Madroñero AB,Ruiz M,Fonollosa V,Simeón CP,RESCLE ADSG(,Callejas E,Calvo E,Carbonell C,Castillo MJ,Chamorro AJ,Colunga D,Corbella X,Egurbide MV,Espinosa G,Fonollosa V,Freire M,García FJ,González R,Guillén Del Castillo A,Iniesta N,Lorenzo R,Madroñero AB,Marí B,Marín A,Ortego N,Pérez M,Pestaña M,Pla X,Ríos JJ,Rodríguez M,Rubio M,Ruiz M,Sáez L,Segovia P,Simeón CP,Soto A,Tarí E,Tolosa C,Trapiella L,Vargas JA,Verdejo G. First clinical symptom as a prognostic factor in systemic sclerosis: results of a retrospective nationwide cohort study. Clin Rheumatol. 2018. 37. (4):p. 999-1009. IF:2,293. (3).