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  3. Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

Two New Fluorogenic Aptasensors Based on Capped Mesoporous Silica Nanoparticles to Detect Ochratoxin A

Data de publicació:

Autors de IIS La Fe

Autors aliens a IIS La Fe

  • Bernardos, A

Grups d'Investigació

Abstract

Aptamers have been used as recognition elements for several molecules due to their great affinity and selectivity. Additionally, mesoporous nanomaterials have demonstrated great potential in sensing applications. Based on these concepts, we report herein the use of two aptamer-capped mesoporous silica materials for the selective detection of ochratoxin A (OTA). A specific aptamer for OTA was used to block the pores of rhodamine B-loaded mesoporous silica nanoparticles. Two solids were prepared in which the aptamer capped the porous scaffolds by using a covalent or electrostatic approach. Whereas the prepared materials remained capped in water, dye delivery was selectively observed in the presence of OTA. The protocol showed excellent analytical performance in terms of sensitivity (limit of detection: 0.5-0.05 nM), reproducibility, and selectivity. Moreover, the aptasensors were tested for OTA detection in commercial foodstuff matrices, which demonstrated their potential applicability in real samples.

Dades de la publicació

ISSN/ISSNe:
2191-1363,

ChemistryOpen  WILEY-V C H VERLAG GMBH

Tipus:
Article
Pàgines:
653-659
PubMed:
29046860
Factor d'Impacte:
1,029 SCImago ℠
Quartil:
Q1 SCImago ℠

Cites Rebudes en Web of Science: 23

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Keywords

  • aptamers; mesoporous materials; nanostructures; ochratoxin A; sensors

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